ArticleClinical epidemiology2018
Intake of glucosinolates and risk of coronary heart disease in three large prospective cohorts of US men and women.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review.Molecules (Basel, Switzerland) · 2020Pooled it
- Trial
- The Antioxidant Properties of Glucosinolates in Cardiac Cells Are Independent of HInternational journal of molecular sciences · 2024Article
- Optimization of ultrasound-assisted extraction of naturally occurring glucosinolates from by-products ofFrontiers in nutrition · 2022Article
- Safety of rapeseed powder fromEFSA journal. European Food Safety Authority · 2020Article
- The Role ofMolecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
importanceGlucosinolates, a group of phytochemicals abundant in cruciferous vegetables, may have cardioprotective properties. However, no prospective study has evaluated the association of intake of glucosinolates with the risk of coronary heart disease (CHD).
objectiveThe objective of the study was to evaluate the association between the intake of glucosinolates and incident CHD in US men and women.
designProspective longitudinal cohort study.
settingHealth professionals in the USA.
participantsWe followed 74,241 women in the Nurses' Health Study (NHS; 1984-2012), 94,163 women in the NHSII (1991-2013), and 42,170 men in the Health Professionals Follow-Up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline. EXPOSURE: Glucosinolate intake was assessed using validated semi-quantitative food frequency questionnaires at baseline and updated every 2-4 years during follow-up.
main outcome measuresIncident cases of CHD were confirmed by medical record review.
resultsDuring 4,824,001 person-years of follow-up, 8,010 cases of CHD were identified in the three cohorts. After adjustment for major lifestyle and dietary risk factors of CHD, weak but significantly positive associations were observed for glucosinolates with CHD risk when comparing the top with bottom quintiles (hazard ratio [HR]:1.09; 95% CI: 1.01, 1.17; CONCLUSION AND RELEVANCE: In these three prospective cohort studies, dietary glucosinolate intake was associated with a slightly higher risk of CHD in US adults. These results warrant replications in further studies including biomarker-based studies. Further studies are needed to confirm these findings and elucidate mechanistic pathways that may underlie these associations.
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Registered trials
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