ReviewPerioperative medicine (London, England)2018
The rising tide of opioid use and abuse: the role of the anesthesiologist.
Review in Perioperative medicine (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05357105 (Rebound Pain Following Surgery With Regional Anesthesia Block), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rebound Pain Following Surgery With Regional Anesthesia Block: A Prospective Cohort Study
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative effectiveness of regional analgesia techniques after gastrectomy for gastric cancer: a systematic review and network meta-analysis of randomized trials.Frontiers in medicine · 2026Pooled it
- Comparative Efficacy of Postoperative Pain Management Techniques Following Costal Cartilage Harvest: A Systematic Review and Network Meta-analysis.Aesthetic plastic surgery · 2025Pooled it
- Duloxetine for the reduction of opioid use in elective orthopedic surgery: a systematic review and meta-analysis.International journal of clinical pharmacy · 2021Pooled it
- The Effect of Ultrasound-Guided Multipoint Thoracic Paravertebral Nerve Block in Metabolic and Bariatric Surgery (MBS): A Prospective Randomized Controlled Trial.Obesity surgery · 2025Trial
- Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.European journal of medical research · 2025Trial
- Opioid-free anesthesia with lidocaine for improved postoperative recovery in hysteroscopy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- Oral acetaminophen as an adjunct to continuous epidural infusion and patient-controlled epidural analgesia in laboring parturients: a randomized controlled trial.Journal of anesthesia · 2021Trial
- Perioperative Opioid Use and Risk of Persistent Use After Common Otolaryngologic Procedures.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Role of Opioid-Free Anesthesia Versus Opioid-Based Anesthesia in Postoperative Pain and Opioid Consumption: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Sustained-release opioid following open abdominal urologic surgery A randomized, controlled study.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Article
- Postoperative Pain Management Strategies Without Regional Analgesia in Knee Surgeries: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- Optimization of multimodal analgesic drug combinations under the concept of precision anesthesia.American journal of translational research · 2026Review
- Metabolic Modulation for Cancer Pain Relief: A Retrospective Pilot Study.Journal of pain research · 2026Article
- Comparison of Opioid Consumption During Paediatric Anaesthesia with and Without a Mandatory Protocol: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- The Efficacy of Magnesium Sulfate in Perioperative Multimodal Analgesia.Current pain and headache reports · 2025Review
- Article
- Regional Anesthesia for Wrist Fractures and Dislocations: Are We Really Blocking Opioid Prescribing?Hand (New York, N.Y.) · 2025Article
- Use of opioids and opioid alternatives during general anesthesia: a pan-Canadian survey among anesthesiologists.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Opioid Free Ptyregopalatine Ganglion Block Based Multimodal Anesthesia Versus Conventional Opioid Based Multimodal Anesthesia for Tonsillectomy Operations: A Randomized Controlled Trial.Anesthesiology and pain medicine · 2024Article
- Opioid-Free Anesthesia in Bariatric Surgery: Is It the One and Only? A Comprehensive Review of the Current Literature.Healthcare (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioid use has risen dramatically in the past three decades. In the USA, opioid overdose has become a leading cause of unintentional death, surpassing motor vehicle accidents. A patient's first exposure to opioids may be during the perioperative period, a time where anesthesiologists have a significant role in pain management. Almost all patients in the USA receive opioids during a surgical encounter. Opioids have many undesirable side effects, including potential for misuse, or opioid use disorder. Anesthesiologists and surgeons employ several methods to decrease unnecessary opioid use, opioid-related adverse events, and side effects in the perioperative period. Multimodal analgesia, enhanced recovery pathways, and regional anesthesia are key tools as we work towards optimal opioid stewardship and the ideal of effective analgesia without undesirable sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.