ArticleImmunity & ageing : I & A2018
Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease.
Article in Immunity & ageing : I & A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators.Journal of neuroinflammation · 2026Article
- Anti-cytomegalovirus antibody levels stratify human immune profiles across the lifespan.GeroScience · 2024Article
- U-shaped association between serum calcium and in-hospital mortality in patients with congestive heart failure.ESC heart failure · 2024Observational
- Epigenetic quantification of immunosenescent CD8Aging cell · 2022Article
- Anti-thymocyte globulin-mediated immunosenescent alterations of T cells in kidney transplant patients.Clinical & translational immunology · 2022Article
- Investigating population-level immunosenescence: From bench to bedside.Frontiers in immunology · 2022Review
- Early immune surveillance to predict cytomegalovirus outcomes after allogeneic hematopoietic stem cell transplantation.Frontiers in cellular and infection microbiology · 2022Article
- CMV infection, CD19Immunity & ageing : I & A · 2021Article
- Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance.International journal of molecular sciences · 2020Review
- Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.BMC nephrology · 2020Article
- Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay Between Innate and Adaptive Immune Dysfunction.International journal of molecular sciences · 2020Review
- Productive Cytomegalovirus Infection Is Associated With Impaired Endothelial Function in ST-Elevation Myocardial Infarction.The American journal of medicine · 2020Article
- Emergence of T cell immunosenescence in diabetic chronic kidney disease.Immunity & ageing : I & A · 2020Article
- "The ancient and the new": is there an interaction between cytomegalovirus and SARS-CoV-2 infection?Immunity & ageing : I & A · 2020Article
- T-cell aging in end-stage renal disease: an evolving story with CMV.Medical microbiology and immunology · 2019Review
- Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing.International journal of molecular sciences · 2019Review
- Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives in Kidney Transplantation.Frontiers in immunology · 2019Review
- A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study.Immunity & ageing : I & A · 2018Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown.
resultsAmong 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2,
conclusionThis is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.