ReviewAcute medicine & surgery2018
Comparison of clinical practice guidelines for the management of pain, agitation, and delirium in critically ill adult patients.
Review in Acute medicine & surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effects of fentanyl administration in mechanically ventilated patients in the intensive care unit: a systematic review and meta-analysis.BMC anesthesiology · 2022Pooled it
- Pooled it
- Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study.PloS one · 2020Trial
- A Multicomponent Communication Intervention to Reduce the Psycho-Emotional Effects of Critical Illness in ICU Patients Related to Their Level of Consciousness: CONECTEM.Journal of clinical medicine · 2026Article
- Article
- Comparative efficacy of remifentanil and fentanyl in mechanically ventilated ICU patients: a systematic review and meta-analysis on ventilation duration and delirium incidence.Journal of anesthesia, analgesia and critical care · 2025Article
- Challenges of the Regional Anesthetic Techniques in Intensive Care Units - A Narrative Review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Review
- Observational
- Pain Management Strategies in Intensive Care Unit: Challenges and Best Practice.Galen medical journal · 2024Article
- Efficacy of Remifentanil in Patients Undergoing Cardiac Surgery: A Systematic Review and Network Meta-Analysis.Cureus · 2023Review
- Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study.Journal of intensive care · 2023Article
- Enhanced recovery after surgery, current, and future considerations in head and neck cancer.Laryngoscope investigative otolaryngology · 2023Review
- Pain in Intensive Care: A Narrative Review.Pain and therapy · 2022Review
- Effect of Comprehensive Pain Management Training Program on Awareness and Attitude of ICU Nurses.Anesthesiology and pain medicine · 2020Article
- Influence of early elective tracheostomy on the incidence of postoperative complications in patients undergoing head and neck surgery.BMC anesthesiology · 2019Observational
- Remifentanil use in intensive care units: Current evidence and future perspectives.Acute medicine & surgeryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guideline-based management approaches for pain, agitation, and delirium (PAD) in critically ill adult patients are widely believed to result in good outcomes. However, there are some differences in the recommendations and evidence levels among the management guidelines established for PAD. To identify and compare the current management guidelines, we used the PubMed database. The PAD guidelines and Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva (FEPIMCTI) guidelines were identified from our search. We compared the main aspects of these two guidelines as well as the Japanese guidelines for the management of PAD (J-PAD guidelines). The PAD, FEPIMCTI, and J-PAD guidelines contained a total of 4, 12, and 5 sections, having 32, 138, and 37 recommendations, respectively, pertaining to routine monitoring of pain in adult patients in the intensive care unit. Intravenous opioids were recommended as the first-line drug of choice for treating pain. Sedative titrated to maintain a light, rather than deep, level of sedation can be given unless clinically contraindicated. Although neither the PAD nor J-PAD guidelines recommend use of a pharmacologic delirium prevention protocol or treatment with any pharmacological agent to reduce the duration of delirium, the FEPIMCTI guidelines provide such recommendations. The FEPIMCTI guidelines provide suggestions on which analgesics to use for several different cases and present algorithms for sedation and analgesia. The outlines of the three guidelines are similar, and all reinforce the management of PAD to improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.