ArticleNeuropsychiatric disease and treatment2018
The effect of depression on fracture healing and osteoblast differentiation in rats.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Relationship between preoperative psychological stress and short-term prognosis in elderly patients with femoral neck fracture.World journal of psychiatry · 2024Article
- Delayed Scaphoid Fracture Union in Patients With Comorbid Psychiatric Diagnoses: A Retrospective Analysis of 20 340 Patients.Hand (New York, N.Y.) · 2024Article
- Assessment of Bone Fracture Healing Using Micro-Computed Tomography.Journal of visualized experiments : JoVE · 2022Article
- The effect of the COVID-19 pandemic on mental health associated trauma, admissions and fractures at a London major trauma centre.Annals of the Royal College of Surgeons of England · 2021Observational
- Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.International journal of molecular sciences · 2020Review
- Nonunions of the humerus - Treatment concepts and results of the last five years.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepressive disorder has been proven to be associated with disturbed bone metabolism. However, the effect of depression on fracture healing still lacks evidence. MATERIALS AND
methodsA rat depressive model was first established by exposing the animals to chronic unpredictable stress, which was assessed using the sucrose preference test, forced swimming test, and open field test. Subsequently, the bone repairing ability was detected by micro-computed tomography and histological analysis of the femoral condyle defect rats with or without depression. To further investigate the potential mechanisms of depression on fracture healing, the osteogenic differentiation and autophagic level were compared between the bone marrow mesenchymal stem cells (BMSCs) derived from depressive and normal rats.
resultsOur results showed that rats with depressive disorder significantly slowed the healing process at 4 and 8 weeks postinjury. Furthermore, the osteogenic potential and autophagy remarkably decreased in BMSCs from the depressive rats, suggesting an inherent relationship between autophagy and osteogenic differentiation. Finally, rapamycin, an autophagic agonist, significantly improved osteogenic differentiation of depressive BMSCs through autophagy activation.
conclusionThe present study indicated that depression had a negative effect on fracture healing with low osteoblast differentiation of BMSCs. Also, autophagy activation in BMSCs offers a novel therapeutic target for depressive patients with poor fracture healing.
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