Evidence map›Paper›PMID 29988633›Full record

ArticleClinical case reports2018

Pulmonary pleomorphic carcinoma with pseudoprogression during nivolumab therapy and the usefulness of tumor markers: A case report.

Akihiro Yoshimura, Chieko Takumi, Taisuke Tsuji, Ryosuke Hamashima, Shinsuke Shiotsu, Tatsuya Yuba, Yoji Urata, Noriya Hiraoka

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akihiro YoshimuraDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.ORCID 0000-0002-3753-2110
Chieko TakumiDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Taisuke TsujiDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Ryosuke HamashimaDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Shinsuke ShiotsuDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Tatsuya YubaDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Yoji UrataDepartment of Clinical Pathology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.
Noriya HiraokaDepartment of Respiratory Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudoprogression was reported as one of the unconventional responses during immune checkpoint inhibitor therapy. A 70-year-old man with pulmonary pleomorphic carcinoma received nivolumab therapy. Pleural effusion and pulmonary metastasis increased, however then shrank and serum cytokeratin 19 fragment levels decreased. Serum tumor marker might help to distinguish pseudoprogression.

Indexed as

immune checkpoint inhibitornivolumabpseudoprogressionpulmonary pleomorphic carcinomatumor marker

Identifiers

PMID29988633
PMCPMC6028417

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.