ArticleFrontiers in integrative neuroscience2018
Inactivation of the Medial-Prefrontal Cortex Impairs Interval Timing Precision, but Not Timing Accuracy or Scalar Timing in a Peak-Interval Procedure in Rats.
Article in Frontiers in integrative neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- Effects of divided attention on movement-related cortical potential in community-dwelling elderly adults: A preliminary study.Heliyon · 2024Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Mice make temporal inferences about novel locations based on previously learned spatiotemporal contingencies.Animal cognition · 2023Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Time Perception in Adult ADHD: Findings from a Decade-A Review.International journal of environmental research and public health · 2023Review
- mPFC catecholamines modulate attentional capture by appetitive distracters and attention to time in a peak-interval procedure in rats.Behavioral neuroscience · 2022Article
- Article
- Temporal scaling and computing time in neural circuits: Should we stop watching the clock and look for its gears?Frontiers in behavioral neuroscience · 2022Article
- Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice.Neuroscience letters · 2021Article
- Medial prefrontal cortex and the temporal control of action.International review of neurobiology · 2021Review
- Striatal dopamine D1 receptors control motivation to respond, but not interval timing, during the timing task.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Article
- Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural Correlates of Interval Timing Deficits in Schizophrenia.Frontiers in human neuroscience · 2019Review
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Motor sequence learning, planning and execution of goal-directed behaviors, and decision making rely on accurate time estimation and production of durations in the seconds-to-minutes range. The pathways involved in planning and execution of goal-directed behaviors include cortico-striato-thalamo-cortical circuitry modulated by dopaminergic inputs. A critical feature of interval timing is its scalar property, by which the precision of timing is proportional to the timed duration. We examined the role of medial prefrontal cortex (mPFC) in timing by evaluating the effect of its reversible inactivation on timing accuracy, timing precision and scalar timing. Rats were trained to time two durations in a peak-interval (PI) procedure. Reversible mPFC inactivation using GABA agonist muscimol resulted in decreased timing precision, with no effect on timing accuracy and scalar timing. These results are partly at odds with studies suggesting that ramping prefrontal activity is crucial to timing but closely match simulations with the Striatal Beat Frequency (SBF) model proposing that timing is coded by the coincidental activation of striatal neurons by cortical inputs. Computer simulations indicate that in SBF, gradual inactivation of cortical inputs results in a gradual decrease in timing precision with preservation of timing accuracy and scalar timing. Further studies are needed to differentiate between timing models based on coincidence detection and timing models based on ramping mPFC activity, and clarify whether mPFC is specifically involved in timing, or more generally involved in attention, working memory, or response selection/inhibition.
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Registered trials
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