ArticleFrontiers in physiology2018
Eight Days of Earth Reambulation Worsen Bone Loss Induced by 1-Month Spaceflight in the Major Weight-Bearing Ankle Bones of Mature Mice.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Spaceflight and the rodent skeleton: A perspective.Bone reports · 2026Review
- Bone strength and composition in spacefaring rodents: systematic review and meta-analysis.NPJ microgravity · 2022Article
- Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?Biomedicines · 2022Review
- Spaceflight-Associated Vascular Remodeling and Gene Expression in Mouse Calvaria.Frontiers in physiology · 2022Article
- Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for MuscleInternational journal of molecular sciences · 2021Article
- Bone health in spacefaring rodents and primates: systematic review and meta-analysis.NPJ microgravity · 2021Article
- The effects of spaceflight microgravity on the musculoskeletal system of humans and animals, with an emphasis on exercise as a countermeasure: a systematic scoping review.Physiological research · 2021Article
- Gravitational Experimental Platform for Animal Models, a New Platform at ESA's Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models.International journal of molecular sciences · 2021Review
- Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation.Scientific reports · 2020Article
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight induces bone alterations with site-specific rates of bone loss according to the weight-bearing function of the bone. For the first time, this study aimed to characterize bone microarchitecture and density alterations of three ankle bones (calcaneus, navicular, and talus) of mice after spaceflight and to evaluate the impact of 8 days of Earth reambulation. Ten C57BL/6N male 4-month-old mice flew on the Bion-M1 biosatellite for 1 month; half were euthanized within 24-h of return and half after 8-days recovery on Earth. Bone microarchitecture and quality was assessed by microtomography (μCT). Whole calcaneus bone volume fraction decreased in Flight group (-6.4%,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.