Evidence map›Paper›PMID 29988521›Full record

ArticleFrontiers in physiology2018

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge.

Ajay K Verma, Da Xu, Michelle Bruner, Amanmeet Garg, Nandu Goswami, Andrew P Blaber, Kouhyar Tavakolian

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04369976 (Estimating the Optimal G Level for Training and Rehabilitation on a Short Arm Human Centrifuge), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04369976 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Estimating the Optimal G Level for Training and Rehabilitation on a Short Arm Human Centrifuge

TypeinterventionalSponsorGreek Aerospace Medical Association and Space ResearchRan2020 to 2025Enrolled105ConditionsMultiple Sclerosis, Stroke, Pulmonary Disease, Chronic Obstructive, AgedArmsARTIFICIAL GRAVITY COMBINED WITH EXERCISE
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ajay K VermaDepartment of Electrical Engineering, University of North Dakota, Grand Forks, ND, United States.
Da XuDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Michelle BrunerDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Amanmeet GargDepartment of Engineering Science, Simon Fraser University, Burnaby, BC, Canada.
Nandu GoswamiPhysiology Division, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
Andrew P BlaberDepartment of Electrical Engineering, University of North Dakota, Grand Forks, ND, United States.
Kouhyar TavakolianDepartment of Electrical Engineering, University of North Dakota, Grand Forks, ND, United States.
Simon Fraser University · CAMedical University of Graz · ATUniversity of North Dakota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomic control of blood pressure is essential toward maintenance of cerebral perfusion during standing, failure of which could lead to fainting. Long-term exposure to microgravity deteriorates autonomic control of blood pressure. Consequently, astronauts experience orthostatic intolerance on their return to gravitational environment. Ground-based studies suggest sporadic training in artificial hypergravity can mitigate spaceflight deconditioning. In this regard, short-arm human centrifuge (SAHC), capable of creating artificial hypergravity of different g-loads, provides an auspicious training tool. Here, we compare autonomic control of blood pressure during centrifugation creating 1-g and 2-g at feet with standing in natural gravity. Continuous blood pressure was acquired simultaneously from 13 healthy participants during supine baseline, standing, supine recovery, centrifugation of 1-g, and 2-g, from which heart rate (RR) and systolic blood pressure (SBP) were derived. The autonomic blood pressure regulation was assessed via spectral analysis of RR and SBP, spontaneous baroreflex sensitivity, and non-linear heart rate and blood pressure causality (RR↔SBP). While majority of these blood pressure regulatory indices were significantly different (

Indexed as

artificial gravityastronautsblood pressure regulationcardiovascular deconditioninglong duration spaceflightmicrogravityorthostatic intoleranceshort-arm human centrifuge

Identifiers

PMID29988521
PMCPMC6026653
OpenAlexW2810414621

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.