ReviewBioactive materials2018
Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective.
Review in Bioactive materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed.
- Full-laser-enabled clean hierarchical structuring and multifunctional synergy for high-performance in vivo 3D-printed implants.Materials today. Bio · 2026Article
- Micropillar Topography Regulates Morphology and Melanogenesis in Melanoma Cells.Journal of functional biomaterials · 2026Article
- Breast Implants: Biomaterials, Surfaces, Biocompatibility-A Biomedical Engineering Perspective.Journal of clinical medicine · 2026Review
- Micro Pattern-Based 3D Cell Culture Platform: An Overview of Technologies and Applications.Exploration (Beijing, China) · 2026Review
- Nerve tissue model on a micropatterned surface: Axon guidance and neural regeneration.Journal of materials science. Materials in medicine · 2025Article
- Bionanomaterials or Nanobiomaterials: Differences in Definitions and Applications.Journal of functional biomaterials · 2025Review
- Topological cues of microparticles train stem cells for tissue repair via mechanotransduction.Bioactive materials · 2025Article
- Corrosion and Biocompatibility Studies of Bioceramic Alumina Coatings on Aluminum Alloy 6082.ACS applied materials & interfaces · 2025Article
- Cellular Signaling at the Nano-Bio Interface: Spotlighting Membrane Curvature.Annual review of physical chemistry · 2025Review
- Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge-Like Framework and Cell Guidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Research progress in the regulation of endothelial cells and smooth muscle cells using a micro-nanostructure.Biomedical engineering online · 2025Review
- On-chip non-contact mechanical cell stimulation - quantification of SKOV-3 alignment to suspended microstructures.Heliyon · 2025Article
- 4D fabrication of shape-changing systems for tissue engineering: state of the art and perspectives.Progress in additive manufacturing · 2025Review
- Extracellular Silica Nanomatrices Promote In Vitro Maturation of Anti-tumor Dendritic Cells via Activation of Focal Adhesion Kinase.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses throughBioactive materials · 2025Article
- Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities.Chemical & biomedical imaging · 2024Article
- Article
- A biodegradable microgrooved and tissue mechanocompatible citrate-based scaffold improves bladder tissue regeneration.Bioactive materials · 2024Article
- Probing Nanotopography-Mediated Macrophage Polarization via Integrated Machine Learning and Combinatorial Biophysical Cue Mapping.ACS nano · 2024Article
- TiOAdvanced materials (Deerfield Beach, Fla.) · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-substrate interactions play a crucial role in the design of better biomaterials and integration of implants with the tissues. Adhesion is the binding process of the cells to the substrate through interactions between the surface molecules of the cell membrane and the substrate. There are several factors that affect cell adhesion including substrate surface chemistry, topography, and stiffness. These factors physically and chemically guide and influence the adhesion strength, spreading, shape and fate of the cell. Recently, technological advances enabled us to precisely engineer the geometry and chemistry of substrate surfaces enabling the control of the interaction cells with the substrate. Some of the most commonly used surface engineering methods for eliciting the desired cellular responses on biomaterials are photolithography, electron beam lithography, microcontact printing, and microfluidics. These methods allow production of nano- and micron level substrate features that can control cell adhesion, migration, differentiation, shape of the cells and the nuclei as well as measurement of the forces involved in such activities. This review aims to summarize the current techniques and associate these techniques with cellular responses in order to emphasize the effect of chemistry, dimensions, density and design of surface patterns on cell-substrate interactions. We conclude with future projections in the field of cell-substrate interactions in the hope of providing an outlook for the future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.