Evidence map›Paper›PMID 29988473›Full record

ArticleClinical epigenetics2018

DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.

Sarah Gonzalez-Nahm, Michelle A Mendez, Sara E Benjamin-Neelon, Susan K Murphy, Vijaya K Hogan, Diane L Rowley, Cathrine Hoyo

Abstract read
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah Gonzalez-Nahm1Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 21205 USA.ORCID 0000-0002-1573-3253
Michelle A Mendez2Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Sara E Benjamin-Neelon1Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 21205 USA.
Susan K Murphy3Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC USA.
Vijaya K Hogan4W.K. Kellogg Foundation, Battle Creek, MI USA.
Diane L Rowley5Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Cathrine Hoyo6Department of Biological Sciences, North Carolina State University, Raleigh, NC USA.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Project 3: Epigenomic Consequences of Early Life Environmental Tobacco Smoke P01ES022831 · NIEHS · DUKE UNIVERSITY · PI MURPHY, SUSAN KAY · 2013 to 2018
$4.1M
Nutrition, Deregulation of Imprinted GenesR01ES016772 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2009 to 2013
$3.1M
Early child care and risk of obesityR01DK094841 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BENJAMIN-NEELON, SARA ELIZABETH · 2012 to 2016
$2.9M
NICHD NIH HHS P2C HD050924NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK094841NIEHS NIH HHS P01 ES022831NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R01 ES016772
6 · The paper itself

Abstract

Background: This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for gestational age Methods: We conducted multiple linear regression in Results: We found an association between higher methylation of the sequences regulating paternally expressed gene 10 ( Conclusion: Our data support a sex-specific association between altered methylation and weight status in early life. These methylation marks can contribute to the compendium of epigenetically regulated regions detectable at birth, influencing obesity in childhood. Larger studies are required to confirm these findings.

Indexed as

DNA MethylationBirth WeightBody Mass IndexChild, PreschoolFemaleFetal BloodGenomic ImprintingGestational AgeHumansInfantInfant, NewbornInfant, Small for Gestational AgeMaleObesityPregnancyChild weightDNA methylationImprinted genes

Identifiers

PMID29988473
PMCPMC6025828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.