Evidence map›Paper›PMID 29988463›Full record

ReviewFrontiers in bioengineering and biotechnology2018

Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance.

Nagarajan Thirunavukkarasu, Eric Johnson, Segaran Pillai, David Hodge, Larry Stanker, Travis Wentz, BalRam Singh, Kodumudi Venkateswaran, Patrick McNutt, Michael Adler and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Botulinum neurotoxin: from molecular pathogenesis to emerging countermeasures.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  3. Article
  4. Review
  5. Equine botulism.Equine veterinary journal · 2026
    Review
  6. Investigating the dual nature ofLe infezioni in medicina · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Genetic Characterization ofAnnals of laboratory medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nagarajan ThirunavukkarasuDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, United States.
Eric JohnsonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States.
Segaran PillaiU.S. Food and Drug Administration Office of Laboratory Science and Safety, Silver Spring, MD, United States.
David HodgeChemical and Biological Defense Division, Science and Technology Directorate, U.S. Department of Homeland Security, Washington, DC, United States.
Larry StankerU.S. Department of Agriculture, Agriculture Research Service Albany, Albany, CA, United States.
Travis WentzDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, United States.
BalRam SinghInstitute of Advanced Sciences, Botulinum Research Center, Dartmouth, MA, United States.
Kodumudi VenkateswaranOmni Array Biotechnology, Rockville, MD, United States.
Patrick McNuttUnited States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States.
Michael AdlerUnited States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States.
Eric BrownDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, United States.
Thomas HammackDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, United States.
Donald BurrOffice of Regulatory Affairs, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Shashi SharmaDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulism outbreak due to consumption of food contaminated with botulinum neurotoxins (BoNTs) is a public health emergency. The threat of bioterrorism through deliberate distribution in food sources and/or aerosolization of BoNTs raises global public health and security concerns due to the potential for high mortality and morbidity. Rapid and reliable detection methods are necessary to support clinical diagnosis and surveillance for identifying the source of contamination, performing epidemiological analysis of the outbreak, preventing and responding to botulism outbreaks. This review considers the applicability of various BoNT detection methods and examines their fitness-for-purpose in safeguarding the public health and security goals.

Indexed as

biosecuritybiosurveillancebotulinum neurotoxinbotulismClostridium botulinumpublic health

Identifiers

PMID29988463
PMCPMC6024544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.