Evidence map›Paper›PMID 29988350›Full record

ArticleInfectious agents and cancer2018

Plasmablastic lymphoma in Malawi.

Takondwa Zuze, Matthew S Painschab, Ryan Seguin, Evarista Kudowa, Bongani Kaimila, Edwards Kasonkanji, Tamiwe Tomoka, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chikasema and 9 more

Abstract read
In one paragraph

Article in Infectious agents and cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy.Mediterranean journal of hematology and infectious diseases · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Takondwa ZuzeUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Matthew S PainschabUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Ryan SeguinUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Evarista KudowaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Bongani KaimilaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Edwards KasonkanjiUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Tamiwe TomokaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Bal Mukunda DhungelUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Maurice Mulenga4Kamuzu Central Hospital, Lilongwe, Malawi.
Maria ChikasemaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Blessings TeweteUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Asekanadziwa NtangwanikaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Sarah ChiyoyolaUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Fred ChimzimuUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Coxcilly KampaniUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Robert KrysiakUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.
Nathan D Montgomery2University of North Carolina, Chapel Hill, USA.
Yuri Fedoriw2University of North Carolina, Chapel Hill, USA.
Satish GopalUNC Project-Malawi, Private Bag, A-104 Lilongwe, Malawi.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
SUPPORTING THE SCALE-UP HIGH QUALITY HIV CARE AND TREATMENT PROGRAMS IN MALAWI U2GPS001965 · PS · UNIVERSITY OF MALAWI · PI KAMIZA, DR. STEVE · 2009 to 2014
$12.9M
Project 3U54CA190152 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, GOPAL, SATISH · 2014 to 2019
$4.2M
Developing a clinical cohort of histopathologically characterized lymphomaK01TW009488 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2012 to 2016
$701k
Molecular profiling of HIV-associated lymphoma in the US and MalawiR21CA180815 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2013 to 2014
$341k
FIC NIH HHS K01 TW009488NCHHSTP CDC HHS U2G PS001965NCI NIH HHS L30 CA233709NCI NIH HHS P30 CA016086NCI NIH HHS R21 CA180815NCI NIH HHS U54 CA190152
6 · The paper itself

Abstract

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24-79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.

Indexed as

EBVEPOCHHIVPlasmablastic lymphomaSub-Saharan Africa

Identifiers

PMID29988350
PMCPMC6022505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.