ArticleParasite epidemiology and control2018
School-aged children based seasonal malaria chemoprevention using artesunate-amodiaquine in Mali.
Article in Parasite epidemiology and control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Seasonal Malaria Chemoprevention.The American journal of tropical medicine and hygiene · 2024Pooled it
- Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses.The Lancet. Global health · 2020Pooled it
- Randomized Field Trial to Assess the Safety and Efficacy of Dihydroartemisinin-Piperaquine for Seasonal Malaria Chemoprevention in School-Aged Children in Bandiagara, Mali.The Journal of infectious diseases · 2024Trial
- Trial
- Trial
- "We are not sick, so why take medicine?" Community perspectives on barriers, facilitators, and implementation strategies for IPTsc in Ghana.Malaria journal · 2026Article
- "After a long day of play, I get tired and forget to unfurl my bed net": a qualitative study exploring factors affecting insecticide-treated bed net use among school-aged children in eastern Uganda.Malaria journal · 2025Article
- Late morning biting behaviour of Anopheles funestus is a risk factor for transmission in schools in Siaya, western Kenya.Malaria journal · 2023Article
- Effect of a fifth round of seasonal malaria chemoprevention in children aged 5-14 years in Dangassa, an area of long transmission in Mali.Parasite epidemiology and control · 2023Article
- Effect of seasonal malaria chemoprevention in children between 5 and 9 years old in Kita and Bafoulabe districts, Mali.Parasite epidemiology and control · 2022Review
- Recent Advances in the Therapeutic Efficacy of Artesunate.Pharmaceutics · 2022Review
- Genome-wide SNP analysis ofFrontiers in genetics · 2022Article
- Effectiveness and Community Acceptance of Extending Seasonal Malaria Chemoprevention to Children 5 to 14 Years of Age in Dangassa, Mali.The American journal of tropical medicine and hygiene · 2021Article
- Maximizing Impact: Can Interventions to Prevent Clinical Malaria Reduce Parasite Transmission?Trends in parasitology · 2020Review
- Effect of routine seasonal malaria chemoprevention on malaria trends in children under 5 years in Dangassa, Mali.Malaria journal · 2020Article
- Effectiveness and safety of intermittent preventive treatment for malaria using either dihydroartemisinin-piperaquine or artesunate-amodiaquine in reducing malaria related morbidities and improving cognitive ability in school-aged children in Tanzania: A study protocol for a controlled randomised trial.Contemporary clinical trials communications · 2020Article
- "Spatial heterogeneity of environmental risk in randomized prevention trials: consequences and modeling".BMC medical research methodology · 2019Article
- Case Definitions of Clinical Malaria in Children from Three Health Districts in the North Region of Cameroon.BioMed research international · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMalaria is still a public health problem in Africa. Seasonal Malaria Chemoprevention (SMC) is an efficient control strategy recommended by WHO that targets children under five year old living in areas of seasonal malaria transmission. SMC uses the combination amodiaquine (AQ) - sulfadoxine-pyrimethamine (SP). However SP selects rapidly drug resistant parasites. And malaria burden may increase in older children where SMC is implemented. We initiated a pilot study to assess an alternative approach to SMC in older children in Mali.
methodsA randomized open-label clinical trial was conducted to test the efficacy and safety of SMC using artesunate - amodiaquine in school aged children in Mali. Two hundred pupils aged 6-15 years old were enrolled and randomized into two arms of 100 each, to receive either artesunate-amodiaquine (ASAQ) monthly or no intervention. Both arms were followed and clinical malaria were diagnosed and treated with arthemeter-lumefanthrine as recommended by Mali National Malaria Control Program. ASAQ was administered 3 days under study team direct observation and during 4 consecutive months starting in October 2013. Follow up was continued until April 2014.
resultsOverall, 20 cases of uncomplicated clinical malaria were encountered in the Control arm and three cases in the ASAQ arm, showing a protective efficacy of 85% 95% CI [80.1-89.9] against clinical malaria. Protective efficacy against malaria infection was 69.6% 95% CI [58.6-21.4]. No effect on anemia was observed. ASAQ was well tolerated. Most common solicited adverse events were abdominal pain and headaches of mild intensity in respectively 64% and 44% of children that swallowed ASAQ.
conclusionASAQ is effective and well tolerated as SMC targeting older children in a
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