Evidence map›Paper›PMID 29988239›Full record

ArticleJournal of atrial fibrillation2018

Recent Trends in Oral Anticoagulant Use and Post-Discharge Complications Among Atrial Fibrillation Patients with Acute Myocardial Infarction.

Amartya Kundu, Kevin O Day, Darleen M Lessard, Joel M Gore, Steven A Lubitz, Hong Yu, Mohammed W Akhter, Daniel Z Fisher, Robert M Hayward, Nils Henninger and 6 more

Abstract read
In one paragraph

Article in Journal of atrial fibrillation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Dual versus triple antithrombotic therapy after percutaneous coronary intervention: the prospective multicentre WOEST 2 Study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Amartya KunduDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
Kevin O DayDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Darleen M LessardDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Joel M GoreDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
Steven A LubitzCardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.
Hong YuDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Mohammed W AkhterDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
Daniel Z FisherDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
Robert M HaywardDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
Nils HenningerDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
Jane S SaczynskiDepartment of Pharmacy and Health System Sciences, Northeastern University, Boston, MA, USA.
Allan J WalkeyDepartment of Medicine, Boston University School of Medicine, Boston, MA.
Alok KapoorDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Jorge YarzebskiDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Robert J GoldbergDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
David D McManusDepartment of Cardiology, University of Massachusetts Medical School, Worcester, MA, USA.
University of Massachusetts Chan Medical School · US

Funding

EHR Anticoagulants PharmacovigilanceR01HL125089 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI YU, HONG · 2015 to 2019
$4.9M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
Community Surveillance of Coronary Heart DiseaseR01HL135219 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOLDBERG, ROBERT JOEL, YU, HONG · 2017 to 2020
$3.2M
Inhibiting axon degeneration in a mouse model of acute brain injury through deletion of Sarm1K08NS091499 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2016 to 2020
$919k
NHLBI NIH HHS R01 HL125089NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01 HL135219NINDS NIH HHS K08 NS091499
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is a common complication of acute myocardial infarction (AMI).The CHA2DS2VAScand CHADS2risk scoresare used to identifypatients with AF at risk for strokeand to guide oral anticoagulants (OAC) use, including patients with AMI. However, the epidemiology of AF, further stratifiedaccording to patients' risk of stroke, has not been wellcharacterized among those hospitalized for AMI.

methodsWe examined trends in the frequency of AF, rates of discharge OAC use, and post-discharge outcomes among 6,627 residents of the Worcester, Massachusetts area who survived hospitalization for AMI at 11 medical centers between 1997 and 2011.

resultsA total of 1,050AMI patients had AF (16%) andthe majority (91%)had a CHA2DS2VAScscore >2.AF rates were highest among patients in the highest stroke risk group.In comparison to patients without AF, patients with AMI and AF in the highest stroke risk category had higher rates of post-discharge complications, including higher 30-day re-hospitalization [27 % vs. 17 %], 30-day post-discharge death [10 % vs. 5%], and 1-year post-discharge death [46 % vs. 18 %] (p < 0.001 for all). Notably, fewerthan half of guideline-eligible AF patientsreceived an OACprescription at discharge. Usage rates for other evidence-based therapiessuch as statins and beta-blockers,lagged in comparison to AMI patients free from AF.

conclusionsOur findings highlight the need to enhance efforts towards stroke prevention among AMI survivors with AF.

Indexed as

AnticoagulationAtrial FibrillationEpidemiologyOutcomes

Identifiers

PMID29988239
PMCPMC6006973
OpenAlexW2807061997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.