ArticleNature medicine2018
Reducing protein oxidation reverses lung fibrosis.
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Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
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Who cites it
83 citing papers in PubMed, 119 citations in OpenAlex.
- Multi-omics Analysis Reveals the Prognostic and Therapeutic Value of TGF-β Signaling-related Genes in Idiopathic Pulmonary Fibrosis.Biochemical genetics · 2026Article
- Grx2 deficiency accelerates BMSC senescence and senile osteoporosis via CD36 S-glutathionylation.Cellular & molecular biology letters · 2026Article
- Integrated in vitro and multi-cohort cross-omics analysis of HTLV-1-associated lung pathology reveals a RelA-dependent mechanism for monocyte recruitment and differentiation.Molecular medicine (Cambridge, Mass.) · 2026Article
- Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis.Communications biology · 2026Article
- Proteomics-Based Study of Potential Emphysema Biomarkers Reveals Systemic Redox System and Extracellular Matrix Component Dysregulation.Diagnostics (Basel, Switzerland) · 2026Article
- Sputum Glutaredoxin 1 and Protein S-Glutathionylation in COPD.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Computational identification of key genetic drivers in COPD: A first step towards uncovering candidate biomarkers in smokers.Biochemistry and biophysics reports · 2025Article
- Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models.Nature communications · 2025Article
- Review
- Post-translational modifications of collagen and its related diseases in metabolic pathways.Acta pharmaceutica Sinica. B · 2025Review
- HDAC11-Mediated Deacetylation of Triosephosphate Isomerase 1 Promotes Idiopathic Pulmonary Fibrosis.Research (Washington, D.C.) · 2025Article
- SCPEP1Frontiers in immunology · 2025Article
- Shared pathogenesis in polycystic ovaries and rheumatoid arthritis: an analysis of key genes and pathways.Frontiers in genetics · 2025Article
- Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation.American journal of respiratory cell and molecular biology · 2024Article
- Strain-dependent glutathionylation of fibronectin fibers impacts mechano-chemical behavior and primes an integrin switch.Nature communications · 2024Article
- Oxidative Stress, Glutaredoxins, and Their Therapeutic Potential in Posterior Capsular Opacification.Antioxidants (Basel, Switzerland) · 2024Review
- Sex-related differences in efficacy of bone marrow-derived high aldehyde dehydrogenase activity cells against pulmonary fibrosis.Stem cell research & therapy · 2024Article
- Endothelial HRedox biology · 2024Article
- Local fractal dimension of collagen detects increased spatial complexity in fibrosis.Histochemistry and cell biology · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 6 institutions in 2 countries.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Karolyn G LahueDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
David G ChapmanDepartment of Medicine, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-8211-1817
Shi B ChiaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Dylan T CaseyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Reem AboushoushaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Jos L J van der VeldenDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Evan ElkoDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Sidra M HoffmanDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
David H McMillanDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Jane T JonesDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
James D NolinDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Sarah AbdallaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Robert SchneiderDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
David J SewardDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Elle C RobersonHonors College, University of Vermont, Burlington, VT, USA.
Matthew D LiptakDepartment of Chemistry, University of Vermont, Burlington, VT, USA.
Morgan E CousinsDepartment of Chemistry, University of Vermont, Burlington, VT, USA.
Kelly J ButnorDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Douglas J TaatjesDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Ralph C BuddDepartment of Medicine, University of Vermont, Burlington, VT, USA.
Charles G IrvinDepartment of Medicine, University of Vermont, Burlington, VT, USA.
Ye-Shih HoInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Razq HakemDepartment of Medical Biophysics and Immunology, University of Toronto, and the Ontario Cancer Institute/University Health Network, Toronto, Ontario, Canada.
Kevin K BrownDepartment of Medicine, Pulmonary, Critical Care and Sleep Section, National Jewish Health and the University of Colorado, Denver, CO, USA.
Reiko MatsuiDepartment of Medicine, Boston University, Boston, MA, USA.
Markus M BachschmidDepartment of Medicine, Boston University, Boston, MA, USA.
Jose L GomezDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Naftali KaminskiDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5917-4601
Albert van der VlietDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA. yvonne.janssen@uvm.edu.
University of Vermont · USBoston University · USYale University · USNational Jewish Health · USOntario Institute for Cancer Research · CAWayne State University · US
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MVERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2006 to 2011
$14.5MLung Genomics Research ConsortiumRC2HL101715 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GERACI, MARK W, KAMINSKI, NAFTALI · 2009 to 2010
$11.4MVermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MS-glutathionylation chemistry in fibrotic lung remodelingR35HL135828 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2017 to 2023
$6.5MMultidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1MREGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNSR01HL060014 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 1999 to 2016
$5.9MDual Oxidase in Airway Epithelial Repair and RemodelingR01HL085646 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2008 to 2020
$4.7MRedox-based Fas Signaling in Allergic Airway DiseaseR01HL079331 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2005 to 2016
$4.2MTranslational Research in Lung Biology and DiseaseP30GM103532 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2012 to 2016
$3.7MEndoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5MEpithelial JNK-TGFb1 Signaling Axis in Airway RemodelingR01HL085464 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2008 to 2016
$3.0MNCATS NIH HHS UL1 TR001430NCI NIH HHS R01 CA219156NCRR NIH HHS P20 RR021905NCRR NIH HHS S10 RR019246NHLBI NIH HHS K01 HL125474NHLBI NIH HHS R01 HL060014NHLBI NIH HHS R01 HL079331NHLBI NIH HHS R01 HL085464NHLBI NIH HHS R01 HL085646NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01 HL133013NHLBI NIH HHS R01 HL137268NHLBI NIH HHS R01 HL138708NHLBI NIH HHS R03 HL095404NHLBI NIH HHS R35 HL135828NHLBI NIH HHS RC2 HL101715NHLBI NIH HHS T32 HL076122NHLBI NIH HHS U01 HL108642NIA NIH HHS R03 AG051857NIDDK NIH HHS R01 DK103750NIGMS NIH HHS P30 GM103532NIGMS NIH HHS P30 GM118228
Abstract
Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the lung, leading to chronically impaired gas exchange and death
Indexed as
AnimalsFemaleGlutaredoxinsGlutathioneIdiopathic Pulmonary FibrosisLungMice, Inbred C57BLMice, TransgenicOxidation-ReductionProteinsGlutaredoxinsGlutathioneProteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.