Evidence map›Paper›PMID 29988085›Full record

SynthesisMolecular psychiatry2019

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.

Jordi Merino, Hassan S Dashti, Sherly X Li, Chloé Sarnowski, Anne E Justice, Misa Graff, Constantina Papoutsakis, Caren E Smith, George V Dedoussis, Rozenn N Lemaitre and 96 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. RNA methylation in vascular disease: a systematic review.Journal of cardiothoracic surgery · 2022
    Pooled it
  2. Pooled it
  3. Meal sugar-protein balance determines postprandial FGF21 response in humans.American journal of physiology. Endocrinology and metabolism · 2023
    Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Smooth muscle cell FTO regulates contractile function.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  15. Article
  16. Article
  17. Urine and FecalMetabolites · 2022
    Article
  18. Polymorphisms, diet and nutrigenomics.Journal of preventive medicine and hygiene · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

106 authors at 20 institutions in 14 countries.

Jordi Merino *Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8312-1438
Hassan S Dashti *Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Sherly X LiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Chloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Anne E JusticeBiomedical and Translational Informatics Institute, Geisinger Health Weis Center for Research, Danvilla, PA, USA.
Misa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Constantina PapoutsakisResearch International and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL, USA.
Caren E SmithNutrition and Genomics, JM-USDA-HNRCA at Tufts University, Boston, MA, USA.
George V DedoussisDepartment of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, Athens, Greece.
Rozenn N LemaitreDepartments of Medicine, University of Washington, Seattle, USA.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Satu MännistöNational Institute for Health and Welfare, Helsinki, Finland.
Julius S NgwaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Minjung KhoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tarunveer S AhluwaliaNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
Natalia PervjakovaNational Institute for Health and Welfare, Helsinki, Finland.
Denise K HoustonDepartment of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Tao HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Peking, China.
Marju Orho-MelanderDepartment of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Alexis C Frazier-WoodUSDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Louis PérusseDepartment of Kinesiology, Faculty of Medicine, Laval University, Québec, Canada.ORCID http://orcid.org/0000-0001-6440-9698
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Callaghan, Australia.
Paul S de VriesHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Trudy VoortmanDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2830-6813
Olivia LiThe Hospital for Sick Children, Translational Medicine, University of Toronto, Toronto, Canada.
Stavroula KanoniWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Nicola M McKeownNutritional Epidemiology, JM-USDA-HNRCA at Tufts University, Boston, MA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Niina EklundNational Institute for Health and Welfare, Helsinki, Finland.
Mike A NallsData Tecnica International, Glen Echo, MD, USA.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Jinyan HuangDepartment of Bioinformatics, Shanghai Institute of Hematology, Shanghai, China.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Christina-Alexandra SchulzDepartment of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Ani ManichaikulCenter for Public Health Genomics, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Québec, Canada.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Callaghan, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Frank J A van RooijDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Jean ShinThe Hospital for Sick Children, Translational Medicine, University of Toronto, Toronto, Canada.
Ioanna P KalafatiDepartment of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, Athens, Greece.
Felix DayMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3789-7651
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Mika KähönenDepartment of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
David S SiscovickNew York Academy of Medicine, New York, NY, USA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Arne AstrupDepartment of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8968-8996
Paul KnektNational Institute for Health and Welfare, Helsinki, Finland.
Melissa GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Qibin QiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Ulrika EricsonDepartment of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Albert HofmanDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Zdenka PausovaThe Hospital for Sick Children, Translational Medicine, University of Toronto, Toronto, Canada.
Vera MikkiläDepartment of Food and Environmental Sciences, Division of Nutrition, Helsinki, Finland.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Antti JulaNational Institute for Health and Welfare, Helsinki, Finland.
Joanne E CurranSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
M Carola ZillikensDepartment of Internal Medicine, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Jorma S ViikariDivision of Medicine, Turku University Hospital, Turku, Finland.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
José M OrdovásNutrition and Genomics, JM-USDA-HNRCA at Tufts University, Boston, MA, USA.
John C LieskeDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Harri RissanenNational Institute for Health and Welfare, Helsinki, Finland.
André G UitterlindenDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Jessica C Kiefte-de JongDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Michael A ProvinceDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Yongmei LiuDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC, USA.
Yun J SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Lu QiDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze-ASF, Florence, Italy.
Stephen S RichDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Angelo TremblayDepartment of Kinesiology, Faculty of Medicine, Laval University, Québec, Canada.
Wendy H OddyTelethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC University Hospital, Rotterdam, The Netherlands.
Tomas PausRotman Research Institute, University of Toronto, Toronto, Canada.
Jose C FlorezCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Panos DeloukasWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9251-070X
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Daniel I Chasman *Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Audrey Y Chu *Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Toshiko Tanaka *Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. tanakato@mail.nih.gov.
Finnish Institute for Health and Welfare · FIUniversity of Cambridge · GBErasmus MC · NLUniversity of Copenhagen · DKWashington University in St. Louis · USBoston University · USBrigham and Women's Hospital · USNational Institute on Aging · USUniversity of Michigan · USUniversity of Toronto · CABroad Institute · USLeiden University Medical Center · NLLund University · SETampere University · FIUniversité Laval · CAUniversity of North Carolina at Chapel Hill · USHarokopio University of Athens · GRMayo Clinic · USPennington Biomedical Research Center · USQueen Mary University of London · GB

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
The Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
The InChianti StudyZIAAG001050 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$2.1M
Genetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1M
Mentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 DiabetesK24DK110550 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2016 to 2020
$812k
Eye and Vision Genomics Training ProgramT32EY022303 · NEI · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2013 to 2017
$799k
Genetic predictors of metabolic responses to dairyK08HL112845 · NHLBI · TUFTS UNIVERSITY BOSTON · PI SMITH, CAREN ELIZABETH · 2013 to 2017
$474k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
British Heart Foundation RG/14/5/30893Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5NCI NIH HHS U01 CA182913NEI NIH HHS T32 EY022303NHLBI NIH HHS K08 HL112845NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS T32 HL007055NIA NIH HHS U01 AG023746NIDDK NIH HHS K24 DK110550NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10

Indexed as

NutrientsAgedAgingAlpha-Ketoglutarate-Dependent Dioxygenase FTOCohort StudiesEnergy IntakeFemaleFibroblast Growth FactorsGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsGenotypeHeart DiseasesHumansMaleAlpha-Ketoglutarate-Dependent Dioxygenase FTODRAM1 protein, humanFGF22 protein, humanFibroblast Growth FactorsFTO protein, humanMembrane ProteinsNutrientsReceptors, Retinoic Acidretinoic acid receptor beta

Identifiers

PMID29988085
PMCPMC6326896
OpenAlexW2868396400

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.