Evidence map›Paper›PMID 29988062›Full record

ReviewBone marrow transplantation2019

Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus statement.

Wilson I Gonsalves, Francis K Buadi, Sikander Ailawadhi, P Leif Bergsagel, Asher A Chanan Khan, David Dingli, Angela Dispenzieri, Rafael Fonseca, Susan R Hayman, Prashant Kapoor and 24 more

Open access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 3 institutions in 1 country.

Wilson I GonsalvesDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA. gonsalves.wilson@mayo.edu.
Francis K BuadiDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Sikander AilawadhiDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida, USA.
P Leif BergsagelDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.ORCID 0000-0003-1523-7388
Asher A Chanan KhanDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida, USA.
David DingliDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Angela DispenzieriDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Rafael FonsecaDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Susan R HaymanDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Prashant KapoorDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Taxiarchis V KourelisDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Martha Q LacyDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Jeremy T LarsenDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Eli MuchtarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2210-2174
Craig B ReederDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Taimur SherDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida, USA.
A Keith StewartDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Rahma WarsameDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Ronald S GoDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Robert A KyleDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Nelson LeungDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-5651-1411
Yi LinDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
John A LustDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Stephen J RussellDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Stephen R ZeldenrustDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Amie L FonderDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Yi L HwaDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Miriam A HobbsDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Angela A MayoDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
William J HoganDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-5841-4105
S Vincent RajkumarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Shaji K KumarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Morie A GertzDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Vivek RoyDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida, USA.
Mayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
Dysregulation of Glutamine Metabolism in the Pathogenesis of Multiple MyelomaK23CA218742 · NCI · MAYO CLINIC ROCHESTER · PI GONSALVES, WILSON · 2017 to 2019
$513k
NCI NIH HHS K23 CA218742NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

Over the last two decades, the utilization of various novel therapies in the upfront or salvage settings has continued to improve survival outcomes for patients with Multiple Myeloma (MM). Thus, the conventional role for hematopoietic stem cell transplantation (HSCT) in MM either in the form of an autologous stem cell transplant (ASCT) or an allogeneic stem cell transplant (Allo-SCT) warrants re-evaluation, given the aforementioned clinical advances. Here, we present a consensus statement of our multidisciplinary group of over 30 Mayo Clinic physicians with a special interest in the care of patients with MM and provide evidence-based recommendations on the use of HSCT in MM. We specifically address topics that include the role and timing of an ASCT for MM in the era of novel agents, eligibility for an ASCT, post-ASCT consolidation, and maintenance options, and finally the utility of an upfront tandem ASCT, salvage second ASCT, and an allo-SCT in MM.

Indexed as

AgedHematopoietic Stem Cell TransplantationHumansMultiple MyelomaTransplantation Conditioning

Identifiers

PMID29988062
PMCPMC6463224
OpenAlexW2819082975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.