Evidence map›Paper›PMID 29987739›Full record

SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018

Predictive Value of Preoperative Sarcopenia in Patients with Gastric Cancer: a Meta-analysis and Systematic Review.

Zhengdao Yang, Xin Zhou, Bin Ma, Yanan Xing, Xue Jiang, Zhenning Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  6. Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  14. Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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  15. Identification of patients at risk for poor survival among those with normal skeletal muscle mass: a multicenter retrospective validation study in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhengdao YangDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Xin ZhouDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110001, China.
Bin MaDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Yanan XingDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China. xingyanan8124@163.com.ORCID 0000-0002-9944-7675
Xue JiangDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Zhenning WangDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe impact of preoperative sarcopenia on postoperative complications and overall survival has been recently debated. Our meta-analysis aims to ascertain whether preoperative sarcopenia increases the risk of poor outcomes and to attempt to provide new ideas for the prognosis of outcomes for patients with gastric cancer.

methodsWe searched for all relevant articles on PubMed, the EMBASE database, and Web of Science (up to September 1, 2017). Data synthesis and statistical analysis were carried out using RevMan 5.3 software.

resultsThirteen studies involving 4262 patients who underwent gastrectomy for gastric cancer were analyzed (sarcopenia group = 1234; non-sarcopenia group = 3028). The results showed that preoperative sarcopenia significantly associated with poor pathological staging (high pT: OR = 1.86, 95% CI = 1.49-2.31; P < 0.01; pN+: OR = 1.61, 95% CI = 1.33-1.94; P < 0.01; high TNM category: OR = 1.84, 95% CI = 1.53-2.22; P < 0.01). Patients with preoperative sarcopenia had an increased risk of total postoperative complications (OR = 2.17, 95% CI = 1.53-3.08; P < 0.01), severe complications (OR = 1.65, 95% CI = 1.09-2.50; P = 0.02), and poorer OS (HR = 1.70, 95% CI = 1.45-1.99; P < 0.01). The results of subgroup analyses revealed that patients with preoperative sarcopenia over 65 years old and those from Asian populations had higher risks for total postoperative complications and severe complications.

conclusionThis meta-analysis reveals that preoperative sarcopenia may be used as a new indicator of poor pathological staging, impaired overall survival, and increased postoperative complications. Notably, patients with gastric cancer who are over 65 years old and from Asia should be routinely screened for sarcopenia before surgery to adequately assess the risk of postoperative complications in clinical practice.

Indexed as

Age FactorsAsian PeopleGastrectomyHumansNeoplasm StagingPostoperative ComplicationsPreoperative PeriodPrognosisRisk FactorsSarcopeniaStomach NeoplasmsSurvival RateGastric cancerOverall survivalPathological stagingPostoperative complicationsSarcopenia

Identifiers

PMID29987739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.