Evidence map›Paper›PMID 29987703›Full record

ArticleMolecular neurobiology2019

Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP

Joanna E Pankiewicz, Sandrine Sanchez, Kent Kirshenbaum, Regina B Kascsak, Richard J Kascsak, Martin J Sadowski

Abstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A New Take on Prion Protein Dynamics in Cellular Trafficking.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joanna E PankiewiczDepartment of Neurology, New York University School of Medicine, 550 First Avenue, Science Building, Room 1007, New York, NY, 10016, USA.
Sandrine SanchezDepartment of Neurology, New York University School of Medicine, 550 First Avenue, Science Building, Room 1007, New York, NY, 10016, USA.
Kent KirshenbaumDepartment of Chemistry, New York University, New York, NY, 10003, USA.
Regina B KascsakNew York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314, USA.
Richard J KascsakNew York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314, USA.
Martin J SadowskiDepartment of Neurology, New York University School of Medicine, 550 First Avenue, Science Building, Room 1007, New York, NY, 10016, USA. sadowm01@med.nyu.edu.ORCID http://orcid.org/0000-0002-3830-1779
New York University · USNew York State Office for People With Developmental Disabilities · US

Funding

Targeting the apoE/A-beta Interaction as a Therapeutic Approach for ADR01AG031221 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2008 to 2020
$4.0M
Mechanisms of Apolipoprotein E Isoform Conferred Susceptibility and Resistance to Alzheimer's DiseaseR01AG053990 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2016 to 2020
$2.1M
Therapeutic Monoclonal Antibodies for Human Prion DiseasesR01AG029635 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2009 to 2010
$761k
National Institute on Aging R01 AG029635National Institute on Aging R01 AG031221National Institute on Aging R01 AG053990National Science Foundation CHE-1507946NIA NIH HHS R01 AG029635NIA NIH HHS R01 AG031221NIA NIH HHS R01 AG053990
6 · The paper itself

Abstract

PrP

Indexed as

Antibodies, MonoclonalAnimalsCell Line, TumorLysosomesMicePrion DiseasesPrion ProteinsProteolysisProteostasisPrPSc ProteinsScrapieAntibodies, MonoclonalPrion ProteinsPrPSc ProteinsEndo-lysosomal systemMonoclonal antibodyPassive immunizationPrion proteinProteostasisPrPSc conformerRecycling propagation

Identifiers

PMID29987703
PMCPMC6326903
OpenAlexW2835715288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.