Evidence map›Paper›PMID 2998764›Full record

ArticleThe EMBO journal1985

The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells.

V Gerke, K Weber

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The EMBO journal, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 258 citations in OpenAlex.

  1. Article
  2. Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025
    Review
  3. Article
  4. Review
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  6. Review
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  8. Article
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  10. Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  11. Article
  12. Review
  13. Article
  14. Dynamic reciprocity: the role of annexin A2 in tissue integrity.Journal of cell communication and signaling · 2014
    Article
  15. Article
  16. G protein-coupled receptors: what a difference a 'partner' makes.International journal of molecular sciences · 2014
    Review
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

V Gerke
K Weber
Max Planck Institute for Biophysical Chemistry · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The major cytoplasmic target of various tyrosine-specific protein kinases is a 36-kd protein (p36). This protein can exist as a monomer or as a complex with a small subunit which seems to have a regulatory function. Amino acid sequence analysis of the small subunit from porcine intestine documents a unique polypeptide of 95 residues with a calculated mol. wt. close to 11 kd (p11). Since an immunologically related subunit of the same electrophoretic mobility is also found in the corresponding complex of chicken intestine p11 is well conserved across species. Unexpectedly, the sequence of p11 shows a high homology with the glia-specific protein S-100 whose biological function is not known. Although both proteins are dimers of rather small polypeptides we have not been able to detect in our preparations of p11 the moderate Ca2+ binding known for S-100. Certain implications of this sequence relation are discussed.

Indexed as

Genes, RegulatorAmino Acid SequenceAnimalsAvian Sarcoma VirusesCattleChickensIntestinesNeurogliaPeptide FragmentsProtein-Tyrosine KinasesS100 ProteinsSequence Homology, Nucleic AcidSpecies SpecificitySwineTrypsinPeptide FragmentsProtein-Tyrosine KinasesS100 ProteinsTrypsin

Identifiers

PMID2998764
PMCPMC554598
OpenAlexW1562745957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.