Evidence map›Paper›PMID 29987591›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2018

Ethanol's Effects on Transient Receptor Potential Channel Expression in Brain Microvascular Endothelial Cells.

Sulie L Chang, Wenfei Huang, Xin Mao, Michelle L Mack

Abstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sulie L ChangInstitute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ, 07079, USA. sulie.chang@shu.edu.
Wenfei HuangInstitute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ, 07079, USA.
Xin MaoInstitute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ, 07079, USA.
Michelle L MackInstitute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ, 07079, USA.
Seton Hall University · US

Funding

Morphine Actions on the Immune SystemK02DA016149 · NIDA · SETON HALL UNIVERSITY · PI CHANG, SULIE L. · 2003 to 2012
$1.1M
Alcohol-induced Impairment of Endothelial Cell RecoveryR21AA024984 · NIAAA · SETON HALL UNIVERSITY · PI CHANG, SULIE L., QIN, XUEBIN · 2017 to 2018
$395k
Involvement of TRP Channels in Ethanol Concentration-Dependent Effects on ImmuneR21AA023172 · NIAAA · SETON HALL UNIVERSITY · PI CHANG, SULIE L. · 2014 to 2015
$353k
NIAAA NIH HHS R21 AA023172NIAAA NIH HHS R21 AA024984NIDA NIH HHS K02 DA016149
6 · The paper itself

Abstract

Ethanol (EtOH), the main ingredient in alcoholic beverages, is well known for its behavioral, physiological, and immunosuppressive effects. There is evidence that EtOH acts through protein targets to exert its physiological effects; however, the mechanisms underlying EtOH's effects on inflammatory processes, particularly at the blood-brain barrier (BBB), are still poorly understood. Transient receptor potential (TRP) channels, the vanguards of human sensory systems, are novel molecular receptors significantly affected by EtOH, and are heavily expressed in brain microvascular endothelial cells (BMVECs), one of the cellular constituents of the BBB. EtOH's actions on endothelial TRP channels could affect intracellular Ca

Indexed as

AnimalsBenzothiazolesBlood-Brain BarrierBrainCell LineDose-Response Relationship, DrugEndothelial CellsEthanolGene ExpressionMiceMicrovesselsTransient Receptor Potential ChannelsTRPM Cation ChannelsBenzothiazolesEthanolnaphtho(1,2-d)thiazol-2-ylamineTransient Receptor Potential ChannelsTrpm7 protein, mouseTRPM Cation ChannelsBlood-brain barrierBrain microvascular endothelial cellsEthanolTransient receptor potential channels

Identifiers

PMID29987591
PMCPMC6431236
OpenAlexW2828989895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.