Evidence map›Paper›PMID 29987517›Full record

ArticleNeuroscience bulletin2018

White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness.

Xuehai Wu, Jiaying Zhang, Zaixu Cui, Weijun Tang, Chunhong Shao, Jin Hu, Jianhong Zhu, Yao Zhao, Lu Lu, Gang Chen and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  19. Disorders of Consciousness in China.Neuroscience bulletin · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Xuehai WuNeurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.ORCID http://orcid.org/0000-0003-4216-6685
Jiaying ZhangState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Zaixu CuiState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Weijun TangRadiological Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
Chunhong ShaoPsychiatry Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jin HuNeurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jianhong ZhuNeurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yao ZhaoNeurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China.
Lu LuHuajia Hospital, Shanghai, 200438, China.
Gang ChenScientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA.
Georg NorthoffInstitute of Mental Health Research, University of Ottawa, Ottawa, ON, K1Z 7K4, Canada.
Gaolang GongState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. gaolang.gong@bnu.edu.cn.
Ying MaoNeurosurgical Department, Shanghai Huashan Hospital, Fudan University, Shanghai, 200040, China. maoying@fudan.edu.cn.
Yong HeState Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Fudan University · CNBeijing Normal University · CNMcGovern Institute for Brain Research · USNational Institutes of Health · USUniversity of Ottawa · CA

Funding

EtOH Modulation of Synaptic Plasticity in Nucleus AccumbensR01AA020501 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARTIN, GILLES E · 2012 to 2016
$1.6M
NIAAA NIH HHS R01 AA020501
6 · The paper itself

Abstract

In this study, we aimed to (1) identify white matter (WM) deficits underlying the consciousness level in patients with disorders of consciousness (DOCs) using diffusion tensor imaging (DTI), and (2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest (ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.

Indexed as

Image Processing, Computer-AssistedAdultBrain StemConsciousnessConsciousness DisordersDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedWhite MatterBrain injuryDiffusion tensor imagingDisorder of consciousnessWhite matter

Identifiers

PMID29987517
PMCPMC6060210
OpenAlexW2812278732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.