ArticleInflammation2018
Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury.
Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Metabolomics reveals McF6'H1-mediated regulation of phenylpropanoid/flavonoid metabolism and enhanced antifungal activity in transgenic Morinda citrifolia.BMC plant biology · 2026Article
- Optimization of Extraction Process for Flavonoids fromMolecules (Basel, Switzerland) · 2026Article
- Luteoloside ameliorates sepsis-induced acute lung injury via AMPK-ULK1 pathway-mediated autophagy.Histology and histopathology · 2025Article
- Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.Scientific reports · 2025Article
- What Do We Know AboutToxics · 2025Review
- Miniature rose alleviates inflammatory bowel disease in mice by modulating gut microbiota, inhibiting TLR4, enhancing tight junction proteins, and promoting metabolism.Frontiers in microbiology · 2025Article
- Caffeic acid inhibits Staphylococcus aureus-induced endometritis through regulating AMPKα/mTOR/HIF-1α signalling pathway.Journal of cellular and molecular medicine · 2024Article
- Anti-inflammatory effect of luteoloside against methylglyoxal induced human dental pulp cells.Journal of applied biomedicine · 2024Article
- Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.Frontiers in pharmacology · 2024Article
- Cynaroside ameliorates methotrexate-induced enteritis in rats through inhibiting NLRP3 inflammasome activation.Frontiers in immunology · 2024Article
- Endometrial responses to bacterial and viral infection: a scoping review.Human reproduction update · 2023Article
- Icariin AlleviatesInternational journal of molecular sciences · 2022Article
- Effects of Intrauterine Infusion of Micronised Purified Flavonoid Fraction (MPFF) in Metritis-Diagnosed Dairy Cows Naturally Infected byVeterinary sciences · 2022Article
- Polysaccharide derived fromAmerican journal of translational research · 2022Article
- Active components and molecular mechanism ofFrontiers in veterinary science · 2022Article
- Ginsenoside Rb1 MitigatesMolecules (Basel, Switzerland) · 2021Article
- Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.International journal of molecular sciences · 2021Article
- Effect of Kangquan Recipe () on BAMBI Expression in Hypothalamic-Pituitary-Prostate in Rats with Benign Prostatic Hyperplasia.Chinese journal of integrative medicine · 2021Article
- Inhibitory Effect of a Rosmarinic Acid-Enriched Fraction Prepared from Nga-Mon (Antioxidants (Basel, Switzerland) · 2021Article
- Galuteolin Inhibited Autophagy for Neuroprotection Against Transient Focal Cerebral Ischemia in Rats.Neuromolecular medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in Staphylococcus aureus-induced endometritis. Histopathological observations and myeloperoxidase (MPO) activity showed that luteoloside could protect the uterus from S. aureus-induced damage and ameliorate the infiltration of inflammatory cells. Quantitative PCR (qPCR) and ELISA analysis also revealed that luteoloside could decrease the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and increase the expression of the anti-inflammatory cytokine IL-10 both in vivo and in vitro. However, western blot analysis revealed that luteoloside inhibited the expression of TLR2 and IL-8 and inhibited the phosphorylation of IκBα and NF-κB p65. Moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (EECs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by S. aureus. Furthermore, this study showed that luteoloside inhibited the expression of Bax but increased the expression of Bcl-2. These results indicate that luteoloside has anti-inflammatory properties by inhibiting the TLR2 and NF-κB signaling pathways and plays an anti-apoptotic role in S. aureus-induced endometritis, which may be valuable for the clinical treatment of S. aureus-induced inflammation.
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