Evidence map›Paper›PMID 29987364›Full record

SynthesisInternational journal of colorectal disease2018

Can sarcopenia be a predictor of prognosis for patients with non-metastatic colorectal cancer? A systematic review and meta-analysis.

Guangwei Sun, Yalun Li, Yangjie Peng, Dapeng Lu, Fuqiang Zhang, Xueyang Cui, Qingyue Zhang, Zhuang Li

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 13 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 13 syntheses or guidelines pooled it, 126 citations in OpenAlex.

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  2. Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Guangwei SunDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Yalun LiDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Yangjie PengDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Dapeng LuDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Fuqiang ZhangDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Xueyang CuiDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Qingyue ZhangDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Zhuang LiDepartment of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, People's Republic of China. cmu1stbill@163.com.ORCID http://orcid.org/0000-0001-9056-7681
First Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to explore whether sarcopenia diagnosed with the third lumbar vertebra skeletal muscle index (L3 SMI) can be a predictor of prognosis for colorectal cancer (CRC) patients.

methodsA systematic review and meta-analysis was conducted using PubMed, Embase, and the Web of Science databases. All original comparative studies published in English that were related to sarcopenia versus non-sarcopenia in non-metastatic CRC patients based on postoperative and survival outcomes were included. Data synthesis and statistical analysis were carried out using Stata software.

resultsA total of 12 studies including 5337 patients were included in our meta-analysis. In our overall analyses of postoperative outcomes, we indicated that CRC patients with sarcopenia would have longer hospital stays, higher incidence of total postoperative morbidity (OR = 1.70, 95% CI = 1.07-2.70, P < 0.01), mortality (OR = 3.45, 95% CI = 1.69-7.02, P < 0.01), and infection (OR = 2.21, 95% CI = 1.50-3.25, P < 0.01) but not anastomosis leakage or intestinal obstruction when compared to non-sarcopenia patients. Regarding survival outcomes, our results showed that sarcopenia predicted a decreased overall survival (HR = 1.63, 95% CI = 1.24-2.14, P < 0.01), disease-free survival, and cancer-specific survival for non-metastatic CRC patients. Moreover, our subgroup analyses showed similar tendency with our overall analyzed results.

conclusionsSarcopenia diagnosed with L3 SMI can be a negative predictor of postoperative and survival outcomes for non-metastatic CRC patients. Prospective studies with a uniform definition of sarcopenia are needed to update our findings.

Indexed as

Colorectal NeoplasmsPrognosisColectomyComorbidityHumansNeoplasm StagingPostoperative ComplicationsRisk FactorsSarcopeniaColorectal cancerMeta-analysisSarcopeniaSkeletal muscle mass

Identifiers

PMID29987364
OpenAlexW2852357199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.