ArticleNanomaterials (Basel, Switzerland)2018
Optical Biosensing System for the Detection of Survivin mRNA in Colorectal Cancer Cells Using a Graphene Oxide Carrier-Bound Oligonucleotide Molecular Beacon.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis.Asian journal of pharmaceutical sciences · 2024Review
- Challenges for Field-Effect-Transistor-Based Graphene Biosensors.Materials (Basel, Switzerland) · 2024Review
- DNA Aptamer Beacon Probe (ABP) for Monitoring of Adenosine Triphosphate Level in SW480 Cancer Cells Treated with Glycolysis Inhibitor 2-Deoxyglucose.International journal of molecular sciences · 2023Article
- The Impact of Molecular Biology in the Seeding, Treatment Choices and Follow-Up of Colorectal Cancer Liver Metastases-A Narrative Review.International journal of molecular sciences · 2023Review
- DNA storage-from natural biology to synthetic biology.Computational and structural biotechnology journal · 2023Review
- Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer.Journal of nanobiotechnology · 2022Review
- 2D Material-Based Optical Biosensor: Status and Prospect.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Visual detection of tropomyosin, a major shrimp allergenic protein using gold nanoparticles (AuNPs)-assisted colorimetric aptasensor.Marine life science & technology · 2021Article
- Promising PEGylated cationic dendrimers for delivery of miRNAs as a possible therapy against HIV-1 infection.Journal of nanobiotechnology · 2021Article
- Gated Resonance Energy Transfer (gRET) Controlled by Programmed Death Protein Ligand 1.Nanomaterials (Basel, Switzerland) · 2020Article
- Graphene Oxide-Assisted Promotion of Plant Growth and Stability.Nanomaterials (Basel, Switzerland) · 2020Article
- MXene Surface on Multiple Junction Triangles for Determining Osteosarcoma Cancer Biomarker by Dielectrode Microgap Sensor.International journal of nanomedicine · 2020Article
- Article
- MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells.Molecules (Basel, Switzerland) · 2018Article
- Investigation of the Effects of Polymer Dispersants on Dispersion of GO Nanosheets in Cement Composites and Relative Microstructures/Performances.Nanomaterials (Basel, Switzerland) · 2018Article
- A Mini Review Focused on the Recent Applications of Graphene Oxide in Stem Cell Growth and Differentiation.Nanomaterials (Basel, Switzerland) · 2018Review
- Hydrothermal Synthesis of Ultra-Light Coal-Based Graphene Oxide Aerogel for Efficient Removal of Dyes from Aqueous Solutions.Nanomaterials (Basel, Switzerland) · 2018Article
- Cement-Induced Coagulation of Aqueous Graphene Oxide with Ultrahigh Capacity and High Rate Behavior.Nanomaterials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-apoptotic protein survivin is one of the most promising cancer biomarkers owing to its high expression in human cancers and rare occurrence in normal adult tissues. In this work, we have investigated the role of supramolecular interactions between a graphene oxide (GO) nanosheet nanocarrier and a survivin molecular beacon (SurMB), functionalized by attaching fluorophore Joe and quencher Dabcyl (SurMB-Joe). Molecular dynamics simulations revealed hydrogen bonding of Joe moiety and Dabcyl to GO carriers that considerably increase the SurMB-GO bonding strength. This was confirmed in experimental work by the reduced fluorescence background in the OFF state, thereby increasing the useful analytical signal range for mRNA detection. A new mechanism of hairpin⁻hairpin interaction of GO@SurMB with target oligonucleotides has been proposed. A low limit of detection, LOD = 16 nM (S/N = 3), has been achieved for complementary tDNA using GO@SurMB-Joe nanocarriers. We have demonstrated an efficient internalization of SurMB-Joe-loaded GO nanocarriers in malignant SW480 cells. The proposed tunability of the bonding strength in the attached motifs for MBs immobilized on nanocarriers, via structural modifications, should be useful in gene delivery systems to enhance the efficacy of gene retention, cell transfection and genomic material survivability in the cellular environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.