Evidence map›Paper›PMID 29987188›Full record

ArticleMolecular and cellular biology2018

Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation.

Ora Haimov, Urmila Sehrawat, Ana Tamarkin-Ben Harush, Anat Bahat, Anna Uzonyi, Alexander Will, Hiroyuki Hiraishi, Katsura Asano, Rivka Dikstein

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Regulation of RNA methylation linked to drug resistance in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
  7. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Eukaryotic translation initiation factorExperimental and therapeutic medicine · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Processing body (P-body) and its mediators in cancer.Molecular and cellular biochemistry · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ora HaimovDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Urmila SehrawatDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Ana Tamarkin-Ben HarushDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Anat BahatDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Anna UzonyiDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Alexander WillDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Hiroyuki HiraishiMolecular and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas, USA.
Katsura AsanoMolecular and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas, USA.
Rivka DiksteinDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel rivka.dikstein@weizmann.ac.il.
Weizmann Institute of Science · ILKansas State University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ACKLEY, BRIAN DOUGLAS · 2001 to 2011
$38.1M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
Studies on start codon selection by eukaryotic ribosomesR01GM064781 · NIGMS · KANSAS STATE UNIVERSITY · PI ASANO, KATSURA · 2002 to 2010
$2.4M
The role of translational control in metabolic stress responseR15GM124671 · NIGMS · KANSAS STATE UNIVERSITY · PI ASANO, KATSURA · 2017 to 2020
$899k
NCRR NIH HHS P20 RR016475NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM110761NIGMS NIH HHS R01 GM064781NIGMS NIH HHS R15 GM124671
6 · The paper itself

Abstract

Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning, except for mRNAs bearing the

Indexed as

5' Untranslated RegionsAmino Acid SequenceBinding SitesEukaryotic Initiation Factor-1Eukaryotic Initiation Factor-4EEukaryotic Initiation Factor-4GEukaryotic Initiation FactorsHEK293 CellsHumansModels, BiologicalModels, MolecularNeoplasm ProteinsNerve Tissue ProteinsPeptide Chain Initiation, TranslationalProtein Interaction Domains and MotifsRibosomes5' Untranslated RegionsEIF1 protein, humanEIF4G1 protein, humanEukaryotic Initiation Factor-1Eukaryotic Initiation Factor-4EEukaryotic Initiation Factor-4GEukaryotic Initiation FactorsNeoplasm ProteinsNerve Tissue ProteinsRNA CapsRNA, MessengerSaccharomyces cerevisiae ProteinseIF1eIF4EeIF4G1leaky scanningTISUtranslation initiation

Identifiers

PMID29987188
PMCPMC6113598
OpenAlexW2810812994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.