ArticleJournal of medical genetics2018
Fine mapping MHC associations in Graves' disease and its clinical subtypes in Han Chinese.
Article in Journal of medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- The association between HLA-B variants and amoxicillin-induced severe cutaneous adverse reactions in Chinese han population.Frontiers in pharmacology · 2024Article
- Contribution ofInternational journal of molecular sciences · 2023Article
- Predisposition to Graves' disease and Graves' ophthalmopathy by genetic variants of IL2RA.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Human leucocyte antigen alleles confer susceptibility and progression to Graves' ophthalmopathy in a Southern Chinese population.The British journal of ophthalmology · 2021Article
- Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide.Acta tropica · 2021Article
- Fine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese.Journal of hepatocellular carcinoma · 2021Article
- Article
- Retrospective in silico HLA predictions from COVID-19 patients reveal alleles associated with disease prognosis.medRxiv : the preprint server for health sciences · 2020Article
- Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis.Hepatology (Baltimore, Md.) · 2019Article
- Article
- Graves Disease Following Subacute Thyroiditis in a Chinese Man.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe classical human leucocyte antigen (HLA) genes were the most important genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal variants of the HLA genes.
methodsWe applied imputation with a Pan-Asian HLA reference panel to thoroughly investigate themajor histocompatibility complex (MHC) associations with GD down to the amino acid level of classical
resultsThe strongest finding across the HLA genes was the association with HLA-DPβ1 position 205 (P
conclusionsFour amino acid positions could account for the associations of MHC with GD in Han Chinese. These distinct
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.