Evidence map›Paper›PMID 29987125›Full record

SynthesisJournal of the American Heart Association2018

Periprocedural Cardiopulmonary Bypass or Venoarterial Extracorporeal Membrane Oxygenation During Transcatheter Aortic Valve Replacement: A Systematic Review.

Saraschandra Vallabhajosyula, Sri Harsha Patlolla, Harigopal Sandhyavenu, Saarwaani Vallabhajosyula, Gregory W Barsness, Shannon M Dunlay, Kevin L Greason, David R Holmes, Mackram F Eleid

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Reporting of sex as a variable in cardiovascular studies using cultured cells: A systematic review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Pooled it
  3. Pooled it
  4. Review
  5. Four-year follow-up after prophylactic awake peripheral veno-arterial ECMO during transcatheter aortic valve replacement.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025
    Article
  6. ECMO in the Cardiac Catheterization Lab-Patient Selection Is Key.Journal of cardiovascular development and disease · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
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  14. Ten-year trends, predictors and outcomes of mechanical circulatory support in percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Saraschandra VallabhajosyulaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Sri Harsha PatlollaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Harigopal SandhyavenuDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Saarwaani VallabhajosyulaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Gregory W BarsnessDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Shannon M DunlayDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Kevin L GreasonDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN.
David R HolmesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Mackram F EleidDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN eleid.mackram@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data on the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) or cardiopulmonary bypass (CPB) to provide hemodynamic support periprocedurally during transcatheter aortic valve replacement. This study sought to evaluate patients receiving transcatheter aortic valve replacement with concomitant use of CPB/VA-ECMO. METHODS AND

resultsWe systematically reviewed the published literature from 2000 to 2018 for studies evaluating adult patients requiring CPB/VA-ECMO periprocedurally during transcatheter aortic valve replacement. Studies reporting short-term and long-term mortality were included. Given the significant methodological and statistical differences between published studies, meta-analysis of the association of CPB/VA-ECMO with mortality was not performed. Of the 537 studies identified, 9 studies representing 5191 patients met our inclusion criteria. Median ages were between 75 and 87 years with 33% to 75% male patients. Where reported, the Edwards SAPIEN™ transcatheter heart valve was the most frequently used. A total of 203 (3.9%) patients received periprocedural hemodynamic support with CPB/VA-ECMO. Common indications for CPB/VA-ECMO included left ventricular or aortic annular rupture, rapid hemodynamic deterioration, aortic regurgitation, cardiac arrest, and left main coronary artery obstruction. The use of CPB/VA-ECMO was predominantly an emergent strategy and was used for durations of 1 to 2 hours. Short-term mortality (in-hospital and 30-day) was 29.8%, and 1-year mortality was 52.4%. Major complications such as bleeding, vascular injury, tamponade, stroke, and renal failure were noted in 10% to 50% of patients.

conclusionsCPB/VA-ECMO was used in 4% in the early experience of patients undergoing transcatheter aortic valve replacement, most commonly for periprocedural complications. There are limited data on preprocedural planned use of VA-ECMO, and the characteristics of this population remain poorly defined.

Indexed as

Aortic ValveAortic Valve StenosisCardiopulmonary BypassExtracorporeal Membrane OxygenationGlobal HealthHumansIncidencePostoperative ComplicationsTranscatheter Aortic Valve Replacementcardiogenic shockcardiopulmonary bypasscritical caremechanical circulatory supporttranscatheter valve implantation

Identifiers

PMID29987125
PMCPMC6064861
OpenAlexW2845102321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.