Evidence map›Paper›PMID 29987104›Full record

ReviewHypertension (Dallas, Tex. : 1979)2018

Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness.

Guanghong Jia, Annayya R Aroor, Michael A Hill, James R Sowers

Abstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. A practical toolbox for modelling fibrosis in vitro.Nature biomedical engineering · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026
    Article
  16. Review
  17. Review
  18. Recent advances and emerging perspectives in vascular and cardiovascular research: A 2025 update.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  19. Article
  20. Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guanghong JiaFrom the Diabetes and Cardiovascular Research Center (G.J., A.R.A., J.R.S.).
Annayya R AroorFrom the Diabetes and Cardiovascular Research Center (G.J., A.R.A., J.R.S.).
Michael A HillDepartment of Medical Pharmacology and Physiology (M.A.H., J.R.S.), University of Missouri School of Medicine, Columbia.
James R SowersFrom the Diabetes and Cardiovascular Research Center (G.J., A.R.A., J.R.S.).

Funding

Role of Cytokine-Induced Inflammation in Endothelial Dysfunction in DiabetesR01HL085119 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI HILL, MICHAEL A · 2007 to 2015
$3.1M
ANG II OPPOSES INS MEDIATED VASORELAXATION &GLU UTILZAR01HL073101 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2004 to 2013
$2.7M
Ang II and Overnutrition and Insulin resistance in Cardiovascular TissueR01HL107910 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2011 to 2015
$1.8M
Interactions of the RAAS and a Western Diet on Insulin Metabolic ActionsI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI LASTRA, GUIDO · 2013 to 2022
–
BLRD VA I01 BX001981NHLBI NIH HHS R01 HL073101NHLBI NIH HHS R01 HL085119NHLBI NIH HHS R01 HL107910
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AldosteroneCardiovascular DiseasesCardiovascular SystemFibrosisHumansHypertensionModels, CardiovascularRenin-Angiotensin SystemRisk FactorsVascular StiffnessAldosterone

Identifiers

PMID29987104
PMCPMC6202147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.