Evidence map›Paper›PMID 29987102›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

SHIP-AHOY (Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth).

Brenda Mendizábal, Elaine M Urbina, Richard Becker, Stephen R Daniels, Bonita E Falkner, Gilad Hamdani, Coral D Hanevold, Stephen R Hooper, Julie R Ingelfinger, Marc Lande and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Brenda MendizábalFrom the Divisions of Preventive Cardiology (B.M., E.M.U.).
Elaine M UrbinaFrom the Divisions of Preventive Cardiology (B.M., E.M.U.).
Richard BeckerHeart, Lung and Vascular Institute, University of Cincinnati College of Medicine, OH (R.B.).
Stephen R DanielsDepartment of Pediatrics, Denver Children's Hospital, Aurora, CO (S.R.D.).
Bonita E FalknerDepartments of Medicine and Pediatrics, Thomas Jefferson University, Philadelphia, PA (B.E.F.).
Gilad HamdaniNephrology (G.H., M.M.).
Coral D HanevoldDivision of Nephrology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine (C.D.H., J.T.F.).
Stephen R HooperDepartment of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill (S.R.H.).
Julie R IngelfingerDepartment of Pediatrics, Harvard Medical School, Mass General Hospital for Children at Massachusetts General Hospital (J.R.I.).
Marc LandeDepartment of Pediatrics, University of Rochester Medical Center, NY (M.L.).
Lisa J MartinHuman Genetics (L.J.M.), Cincinnati Children's Hospital Medical Center, OH.
Kevin MeyersPediatric Nephrology, Children's Hospital of Philadelphia, PA (K.M.).
Mark MitsnefesFrom the Divisions of Preventive Cardiology (B.M., E.M.U.).
Bernard RosnerDepartment of Medicine, Harvard Medical School, Boston, MA (B.R.).
Joshua A SamuelsPediatric Nephrology and Hypertension, University of Texas Health Science Center at Houston (J.A.S.).
Joseph T FlynnDivision of Nephrology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine (C.D.H., J.T.F.).

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Short Term Medical Student Training GrantT35DK060444 · NIDDK · UNIVERSITY OF CINCINNATI · PI JASON T BLACKARD · 2002 to 2026
$2.3M
NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR002319NIDDK NIH HHS T35 DK060444
6 · The paper itself

Abstract

Although hypertension is identifiable in children and adolescents, there are many knowledge gaps on how to best define and manage high blood pressure in the young. SHIP-AHOY (Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth) is being conducted to address these knowledge gaps. Five hundred adolescents will be recruited and will undergo ambulatory blood pressure monitoring, echocardiographic, vascular, and cognitive assessments, as well as epigenetic studies to identify mechanisms that underlie the development of hypertensive target organ damage. Details of the design and methods that will be utilized in SHIP-AHOY are presented here, as well as baseline characteristics of the first 264 study participants. The primary aim of the study is to develop a risk-based definition of hypertension in the young that will result in better understanding of the transition from blood pressure in youth to adult cardiovascular disease.

Indexed as

Research DesignAdolescentAdultBlood PressureBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesChildDNA MethylationEchocardiographyFemaleGene Expression ProfilingHumansHypertensionMaleMicroRNAsRisk FactorsMicroRNAsadolescentsblood pressurecardiovascular diseasehypertensionvascular stiffness

Identifiers

PMID29987102
PMCPMC6202222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.