Evidence map›Paper›PMID 29987045›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Scleral hypoxia is a target for myopia control.

Hao Wu, Wei Chen, Fei Zhao, Qingyi Zhou, Peter S Reinach, Lili Deng, Li Ma, Shumeng Luo, Nethrajeith Srinivasalu, Miaozhen Pan and 15 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 9 pooled it
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 9 syntheses or guidelines pooled it, 489 citations in OpenAlex.

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  10. Effect of 0.01% Atropine on Choroidal Thickness and Ocular Growth in Pre-myopic Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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  16. Three-year cohort study on the predictive role of axial length-to-corneal radius ratio in the incidence and progression of myopia among Chinese schoolchildren.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  17. Article
  18. Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  19. Review
  20. Article

239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

Hao WuSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.ORCID 0000-0001-8448-5284
Wei ChenKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, The Chinese Academy of Sciences, 100101 Beijing, China.
Fei ZhaoSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Qingyi ZhouSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Peter S ReinachSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Lili DengKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, The Chinese Academy of Sciences, 100101 Beijing, China.
Li MaSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Shumeng LuoKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, The Chinese Academy of Sciences, 100101 Beijing, China.
Nethrajeith SrinivasaluSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Miaozhen PanSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Yang HuSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Xiaomeng PeiSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Jing SunSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Ran RenSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Yinghui XiongSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Zhonglou ZhouSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Sen ZhangSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China.
Geng TianGenomic and Synthetic Biology Core Facility, Tsinghua University, 100084 Beijing, China.
Jianhuo FangGenomic and Synthetic Biology Core Facility, Tsinghua University, 100084 Beijing, China.
Lina ZhangGenomic and Synthetic Biology Core Facility, Tsinghua University, 100084 Beijing, China.
Jidong LangGenomic and Synthetic Biology Core Facility, Tsinghua University, 100084 Beijing, China.
Deng WuKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, The Chinese Academy of Sciences, 100101 Beijing, China.
Changqing ZengKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, The Chinese Academy of Sciences, 100101 Beijing, China; czeng@big.ac.cn jqu@wmu.edu.cn zxt@mail.eye.ac.cn.
Jia QuSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China; czeng@big.ac.cn jqu@wmu.edu.cn zxt@mail.eye.ac.cn.
Xiangtian ZhouSchool of Optometry and Ophthalmology Wenzhou Medical University, Wenzhou, 325027 Zhejiang, China; czeng@big.ac.cn jqu@wmu.edu.cn zxt@mail.eye.ac.cn.
Wenzhou Medical University · CNChinese Academy of Sciences · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate extension of the ocular axis and concomitant declines in scleral strength and thickness caused by extracellular matrix (ECM) remodeling. However, the identities of the initiators and signaling pathways that induce scleral ECM remodeling in myopia are unknown. Here, we used single-cell RNA-sequencing to identify pathways activated in the sclera during myopia development. We found that the hypoxia-signaling, the eIF2-signaling, and mTOR-signaling pathways were activated in murine myopic sclera. Consistent with the role of hypoxic pathways in mouse model of myopia, nearly one third of human myopia risk genes from the genome-wide association study and linkage analyses interact with genes in the hypoxia-inducible factor-1α (HIF-1α)-signaling pathway. Furthermore, experimental myopia selectively induced HIF-1α up-regulation in the myopic sclera of both mice and guinea pigs. Additionally, hypoxia exposure (5% O

Indexed as

HypoxiaSignal TransductionAnimalsDisease Models, AnimalEukaryotic Initiation Factor-2Extracellular MatrixEye ProteinsGuinea PigsHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMyopiaScleraTOR Serine-Threonine KinasesEukaryotic Initiation Factor-2Eye ProteinsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitmTOR protein, mouseTOR Serine-Threonine KinasesHIF-1αmyopiascleral ECM remodelingscleral hypoxiascRNA-seq

Identifiers

PMID29987045
PMCPMC6064999
OpenAlexW2842736086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.