Evidence map›Paper›PMID 29987035›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

GC content elevates mutation and recombination rates in the yeast

Denis A Kiktev, Ziwei Sheng, Kirill S Lobachev, Thomas D Petes

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 134 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Extended sequence context shapes mutational bias inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Census and genetic analysis of the United States marmoset population.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Mutations and structural variants arising during double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. The complete chloroplast genome ofFrontiers in plant science · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Denis A KiktevDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710.
Ziwei ShengSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Kirill S LobachevSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Thomas D PetesDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710; tom.petes@duke.edu.
Duke University · USGeorgia Institute of Technology · US

Funding

Genetic regulation of genome stability in yeastR35GM118020 · NIGMS · DUKE UNIVERSITY · PI PETES, THOMAS · 2016 to 2025
$7.0M
RECOMBINATION IN YEASTR01GM024110 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PETES, THOMAS · 1985 to 2015
$6.1M
INSTABILITY OF SIMPLE REPETITIVE DNA SEQUENCES IN YEASTR01GM052319 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PETES, THOMAS · 1995 to 2015
$4.9M
NIGMS NIH HHS R01 GM024110NIGMS NIH HHS R01 GM052319NIGMS NIH HHS R35 GM118020
6 · The paper itself

Abstract

The chromosomes of many eukaryotes have regions of high GC content interspersed with regions of low GC content. In the yeast

Indexed as

Base CompositionBase SequenceRecombination, GeneticSequence DeletionSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiae ProteinsURA3 protein, S cerevisiaeerror-prone DNA polymerasehigh GC contentmeiotic recombinationmitotic recombinationmutations

Identifiers

PMID29987035
PMCPMC6064992
OpenAlexW2831164565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.