ArticleProceedings of the National Academy of Sciences of the United States of America2018
Preordering of water is not needed for ice recognition by hyperactive antifreeze proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 118 citations in OpenAlex.
- An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Fully Atomistic Molecular Dynamics Simulation of Ice Nucleation Near an Antifreeze Protein.Journal of the American Chemical Society · 2025Article
- On the engulfment of antifreeze proteins by ice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Monitoring water harvesting in metal-organic frameworks, one water molecule at a time.Chemical science · 2024Article
- Multiscale Molecular Dynamics Simulations of Ice-Binding Proteins.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- De novo designed ice-binding proteins from twist-constrained helices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Janus regulation of ice growth by hyperbranched polyglycerols generating dynamic hydrogen bonding.Nature communications · 2022Article
- Water-organizing motif continuity is critical for potent ice nucleation protein activity.Nature communications · 2022Article
- Ice-binding proteins and bioinspired synthetic mimics in non-physiological environments.iScience · 2022Review
- Screening toward the Development of Fingerprints of Atomic Environments Using Bond-Orientational Order Parameters.ACS omega · 2022Article
- High Water Density at Non-Ice-Binding Surfaces Contributes to the Hyperactivity of Antifreeze Proteins.The journal of physical chemistry letters · 2021Article
- Synergistic Ice Inhibition Effect Enhances Rapid Freezing Cryopreservation with Low Concentration of Cryoprotectants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Fish-Derived Antifreeze Proteins and Antifreeze Glycoprotein Exhibit a Different Ice-Binding Property with Increasing Concentration.Biomolecules · 2020Article
- Hydrogen bonding structure of confined water templated by a metal-organic framework with open metal sites.Nature communications · 2019Article
- Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer "Active"?Macromolecular bioscience · 2019Review
- Ice-binding proteins and the applicability and limitations of the kinetic pinning model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Combined molecular dynamics and neural network method for predicting protein antifreeze activity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Antifreeze protein hydration waters: Unstructured unless bound to ice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antifreeze proteins (AFPs) inhibit ice growth in organisms living in cold environments. Hyperactive insect AFPs are particularly effective, binding ice through "anchored clathrate" motifs. It has been hypothesized that the binding of hyperactive AFPs to ice is facilitated by preordering of water at the ice-binding site (IBS) of the protein in solution. The antifreeze protein
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.