Evidence map›Paper›PMID 29986944›Full record

ArticleJournal of bacteriology2018

A Defective Undecaprenyl Pyrophosphate Synthase Induces Growth and Morphological Defects That Are Suppressed by Mutations in the Isoprenoid Pathway of Escherichia coli.

William J MacCain, Suresh Kannan, Dannah Z Jameel, Jerry M Troutman, Kevin D Young

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

William J MacCainDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Suresh KannanDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Dannah Z JameelDepartment of Chemistry, University of North Carolina Charlotte, Charlotte, North Carolina, USA.
Jerry M TroutmanDepartment of Chemistry, University of North Carolina Charlotte, Charlotte, North Carolina, USA.
Kevin D YoungDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA kdyoung@uams.edu.ORCID 0000-0003-1760-281X
University of Arkansas for Medical Sciences · USUniversity of North Carolina at Charlotte · US

Funding

Glycan Expression Analysis using an Odyssey CLx Infrared Imaging SystemR01GM061019 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI VOTH, DANIEL E · 2000 to 2021
$8.0M
In vitro and Cellular Tools for Complex Polysaccharide BiosynthesisR01GM123251 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TROUTMAN, JERRY M · 2017 to 2023
$2.1M
Toolkit development for bacterial isoprenoid utilizing enzymesR15GM114773 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TROUTMAN, JERRY M · 2015 to 2015
$350k
NIGMS NIH HHS R01 GM061019NIGMS NIH HHS R01 GM123251NIGMS NIH HHS R15 GM114773
6 · The paper itself

Abstract

The peptidoglycan exoskeleton shapes bacteria and protects them against osmotic forces, making its synthesis the target of many current antibiotics. Peptidoglycan precursors are attached to a lipid carrier and flipped from the cytoplasm into the periplasm to be incorporated into the cell wall. In

Indexed as

MutationAlkyl and Aryl TransferasesBiosynthetic PathwaysEscherichia coliEscherichia coli ProteinsPeptidoglycanPolyisoprenyl PhosphatesAlkyl and Aryl TransferasesEscherichia coli ProteinsPeptidoglycanPolyisoprenyl Phosphatesundecaprenyl pyrophosphateundecaprenyl pyrophosphate synthetaseisoprenoidisoprenoidsmorphologypeptidoglycanundecaprenyl phosphateUnd-PUppS

Identifiers

PMID29986944
PMCPMC6112006
OpenAlexW2858597822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.