Evidence map›Paper›PMID 29986898›Full record

ReviewDevelopment (Cambridge, England)2018

TOR signaling in plants: conservation and innovation.

Lin Shi, Yue Wu, Jen Sheen

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 223 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Plant signaling & behavior · 2025
    Article
  12. The plant epigenome governed by nutrients and metabolism.Current opinion in plant biology · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lin ShiDepartment of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Yue WuDepartment of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Jen SheenDepartment of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA sheen@molbio.mgh.harvard.edu.ORCID 0000-0001-8970-9267
Harvard University · US

Funding

Glucose Signal Transduction Pathways in PlantsR01GM060493 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEEN, JEN · 2000 to 2017
$5.7M
Signaling Mechanisms in Plant Innate ImmunityR01GM070567 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEEN, JEN · 2005 to 2017
$4.2M
Plant Nutrient-Growth Signaling NetworkR01GM129093 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEEN, JEN · 2018 to 2025
$2.8M
NIGMS NIH HHS R01 GM060493NIGMS NIH HHS R01 GM070567NIGMS NIH HHS R01 GM129093
6 · The paper itself

Abstract

Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that plays a central role in both plants and animals, despite their distinct developmental programs and survival strategies. Indeed, TOR integrates nutrient, energy, hormone, growth factor and environmental inputs to control proliferation, growth and metabolism in diverse multicellular organisms. Here, we compare the molecular composition, upstream regulators and downstream signaling relays of TOR complexes in plants and animals. We also explore and discuss the pivotal functions of TOR signaling in basic cellular processes, such as translation, cell division and stem/progenitor cell regulation during plant development.

Indexed as

Plant DevelopmentPlant ProteinsPlantsSignal TransductionTOR Serine-Threonine KinasesPlant ProteinsTOR Serine-Threonine KinasesCell cycle regulationMeristemMetabolism reprogrammingNutrient signalingStem cell nicheTarget of rapamycin protein kinase

Identifiers

PMID29986898
PMCPMC6053665
OpenAlexW2857309776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.