Evidence map›Paper›PMID 29986897›Full record

ArticleGenetics2018

Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in

Brandt Warecki, William Sullivan

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Double-checking chromosome segregation.The Journal of cell biology · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Dephosphorylation in nuclear reassembly after mitosis.Frontiers in cell and developmental biology · 2022
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Mechanisms driving acentric chromosome transmission.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Brandt WareckiDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064.
William SullivanDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064 wtsulliv@ucsc.edu.
University of California, Santa Cruz · US

Funding

Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
Mitotic transmission of acentric chromosomesR35GM139595 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI William T. SULLIVAN · 2021 to 2026
$2.5M
Mechanisms of Acentric Chromosome TransmissionR01GM120321 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SULLIVAN, WILLIAM T. · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM120321NIGMS NIH HHS R35 GM139595NIGMS NIH HHS T32 GM008646
6 · The paper itself

Abstract

While it is known that micronuclei pose a serious risk to genomic integrity by undergoing chromothripsis, mechanisms preventing micronucleus formation remain poorly understood. Here, we investigate how late-segregating acentric chromosomes that would otherwise form micronuclei instead reintegrate into daughter nuclei by passing through Aurora B kinase-dependent channels in the nuclear envelope of

Indexed as

AnimalsAurora Kinase BCell NucleusChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNADrosophila melanogasterDrosophila ProteinsHeterochromatinMicronuclei, Chromosome-DefectiveMicronucleus, GermlineNuclear EnvelopeAurB protein, DrosophilaAurora Kinase BChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNADrosophila ProteinsHeterochromatinacentricgenome integritymicronucleinuclear envelope

Identifiers

PMID29986897
PMCPMC6116970
OpenAlexW2854244202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.