Evidence map›Paper›PMID 29986891›Full record

ArticleInfection and immunity2018

Courtney E Chandler, Erin M Harberts, Tim Laemmermann, Qin Zeng, Belita N Opene, Ronald N Germain, Christopher M Jewell, Alison J Scott, Robert K Ernst

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Progress in microneedle array patch (MAP) for vaccine delivery.Human vaccines & immunotherapeutics · 2021
    Article
  7. Review
  8. Microneedle Coating Methods: A Review with a Perspective.The Journal of pharmacology and experimental therapeutics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Courtney E ChandlerDepartment of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Erin M HarbertsDepartment of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Tim LaemmermannLaboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Qin ZengFischell Department of Bioengineering, University of Maryland-College Park, College Park, Maryland, USA.
Belita N OpeneDepartment of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Ronald N GermainLaboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Christopher M JewellFischell Department of Bioengineering, University of Maryland-College Park, College Park, Maryland, USA.
Alison J Scott *Department of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Robert K Ernst *Department of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, Maryland, USA rkernst@umaryland.edu.ORCID https://orcid.org/0000-0001-5016-8694
University of Maryland, Baltimore · USNational Institute of Allergy and Infectious Diseases · USUnited States Department of Veterans Affairs · USUniversity of Maryland, College Park · US

Funding

Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4M
Analysis of Host-Pathogen InteractionsZIAAI001034 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2021
$7.9M
Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
NIAID NIH HHS T32 AI095190
6 · The paper itself

Abstract

Infectious diseases propagated by arthropod vectors, such as tularemia, are commonly initiated via dermal infection of the skin. However, due to the technical difficulties in achieving accurate and reproducible dermal deposition, intradermal models are less commonly used. To overcome these limitations, we used microneedle arrays (MNAs), which are micron-scale polymeric structures, to temporarily disrupt the barrier function of the skin and deliver a bacterial inoculum directly to the dermis of an animal. MNAs increase reliability by eliminating leakage of the inoculum or blood from the injection site, thereby providing a biologically relevant model for arthropod-initiated disease. Here, we validate the use of MNAs as a means to induce intradermal infection using a murine model of tularemia initiated by

Indexed as

NeedlesAnimalsAntibodies, BacterialBacterial VaccinesDermisDisease Models, AnimalFemaleFrancisellaImmunizationInjections, IntradermalInterleukin-6MiceMice, Inbred C57BLMutationReproducibility of ResultsSkinAntibodies, BacterialBacterial VaccinesInterleukin-6interleukin-6, mouseVaccines, AttenuatedFrancisellainfection modelintradermalmicroneedles

Identifiers

PMID29986891
PMCPMC6105887
OpenAlexW2839808766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.