Evidence map›Paper›PMID 29986881›Full record

ArticleThe Journal of biological chemistry2018

Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations.

Elisabet C Mandon, Cameron Butova, Amber Lachapelle, Reid Gilmore

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisabet C MandonFrom the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Cameron ButovaFrom the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Amber LachapelleFrom the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Reid GilmoreFrom the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 reid.gilmore@umassmed.edu.ORCID 0000-0002-1656-4041
University of Massachusetts Chan Medical School · US

Funding

PROTEIN TRANSLOCATION ACROSS THE ENDOPLASMIC RETICULUMR01GM035687 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GILMORE, JAMES REID · 1985 to 2019
$5.9M
NIGMS NIH HHS R01 GM035687
6 · The paper itself

Abstract

The Sec61 complex is the primary cotranslational protein translocation channel in yeast (

Indexed as

Amino Acid MotifsAmino Acid SequenceAmino Acid SubstitutionConserved SequenceModels, MolecularProtein BindingProtein ConformationProtein MultimerizationRibosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSEC Translocation ChannelsSaccharomyces cerevisiae ProteinsSEC61 protein, S cerevisiaeSEC Translocation Channelsendoplasmic reticulum (ER)membrane proteinprotein synthesisprotein translocationribosomeSec61translocation channel

Identifiers

PMID29986881
PMCPMC6120202
OpenAlexW2812976466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.