Evidence map›Paper›PMID 29986688›Full record

ArticleBMC pediatrics2018

Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial.

R Chingono, H Mebrahtu, Z Mupambireyi, V Simms, H A Weiss, P Ndlovu, F Charasika, M Tomlinson, L D Cluver, F M Cowan and 1 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

R ChingonoCentre for Sexual Health HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
H MebrahtuDepartment of Infection and Population Health, University College London, London, UK. helen.mebrahtu.15@ucl.ac.uk.ORCID 0000-0001-9664-5003
Z MupambireyiCentre for Sexual Health HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
V SimmsMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
H A WeissMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
P NdlovuWorld Education Inc./Bantwana (WEI/B), Harare, Zimbabwe.
F CharasikaWorld Education Inc./Bantwana (WEI/B), Harare, Zimbabwe.
M TomlinsonDepartment of Psychology, Stellenbosch University, Stellenbosch, South Africa.
L D CluverUniversity of Cape Town, Cape Town, South Africa.
F M CowanCentre for Sexual Health HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
L SherrDepartment of Infection and Population Health, University College London, London, UK.
Centre for Sexual Health and HIV AIDS Research · ZWLondon School of Hygiene & Tropical Medicine · GBUniversity College London · GBWorld Education · USLiverpool School of Tropical Medicine · GBStellenbosch University · ZAUniversity of Cape Town · ZA

Funding

Medical Research Council MR/K012126/1PEPFAR
6 · The paper itself

Abstract

backgroundHIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.

methodsThe study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. DISCUSSION: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.

trial registrationThis trial is registered with the Pan African Clinical Trials Registry ( www.pactr.org ), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered).

Indexed as

Child DevelopmentChild RearingHIV InfectionsParentsAdultAnti-HIV AgentsChild, PreschoolCognitionDisease ManagementHumansIncomeInfantInfant, NewbornMulticenter Studies as TopicPovertyProgram EvaluationAnti-HIV AgentsCase managementEarly childhood stimulationHIV exposed infantsInternal savings and lending schemeZimbabwe

Identifiers

PMID29986688
PMCPMC6038232
OpenAlexW2875998383

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.