Evidence map›Paper›PMID 29986399›Full record

ArticleViruses2018

Anti-Infectivity against Herpes Simplex Virus and Selected Microbes and Anti-Inflammatory Activities of Compounds Isolated from

Viliam Brezáni, Veronika Leláková, Sherif T S Hassan, Kateřina Berchová-Bímová, Pavel Nový, Pavel Klouček, Petr Maršík, Stefano Dall'Acqua, Jan Hošek, Karel Šmejkal

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 80 citations in OpenAlex.

  1. Synthesis and Biological Assessment of Eucalyptin: Magic Methyl Effects.International journal of molecular sciences · 2025
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  8. Molecules (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Viliam BrezániDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1946/1, 612 42 Brno, Czech Republic. brezani.viliam@gmail.com.
Veronika LelákováDepartment of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1946/1, 612 42 Brno, Czech Republic. veronika.lelakova@gmail.com.
Sherif T S HassanDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1946/1, 612 42 Brno, Czech Republic. sherif.hassan@seznam.cz.ORCID 0000-0003-3922-2738
Kateřina Berchová-BímováDepartment of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Praha 6-Suchdol, Czech Republic. berchova@knc.czu.cz.
Pavel NovýDepartment of Quality of Agricultural Products, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Praha 6-Suchdol, Czech Republic. novy@af.czu.cz.ORCID 0000-0001-7524-1173
Pavel KloučekDepartment of Quality of Agricultural Products, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Praha 6-Suchdol, Czech Republic. kloucek@af.czu.cz.
Petr MaršíkDepartment of Quality of Agricultural Products, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Praha 6-Suchdol, Czech Republic. marsik@af.czu.cz.
Stefano Dall'AcquaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Via F. Marzolo 5, 351 31 Padua, Italy. stefano.dallacqua@unipd.it.ORCID 0000-0001-8264-6953
Jan HošekDepartment of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1946/1, 612 42 Brno, Czech Republic. hosekj@vfu.cz.ORCID 0000-0003-0975-1671
Karel ŠmejkalDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1946/1, 612 42 Brno, Czech Republic. karel.mejkal@post.cz.
University of Veterinary Sciences Brno · CZCzech University of Life Sciences Prague · CZUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus (HSV) causes numerous mild-to-serious human diseases, including mucocutaneous herpes infections and life-threatening herpes encephalitis. Moreover, herpes viral lesions can be complicated by inflammation and secondary bacterial infections. The development of resistance to antiviral drugs along with the undesirable side effects of these drugs are relevant argue for the development of new anti-HSV drugs with diverse mechanisms of action.

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantsAntiviral AgentsCell LineCell SurvivalChlorocebus aethiopsCytokinesEucalyptusHerpes SimplexHumansNF-kappa BPlant ExtractsReactive Oxygen SpeciesAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantsAntiviral AgentsCytokinesNF-kappa BPlant ExtractsReactive Oxygen SpeciesTranscription Factor AP-1antibacterialantiherpeticanti-inflammatoryEucalyptusHSV-1HSV-2IL-1βNF-κB/AP-1ROSTNF-α

Identifiers

PMID29986399
PMCPMC6070903
OpenAlexW2814097638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.