ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Performance of Treponemal Tests for the Diagnosis of Syphilis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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51 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Innovations and Challenges in Syphilis Screening and Prevention Among Men Who Have Sex With Men: A Scoping Review.Sexually transmitted diseases · 2026Article
- Comparison of CDC and ECDC reverse sequence algorithms for syphilis diagnosis: clinical implications of discordant serological results.BMC infectious diseases · 2026Article
- Article
- Differentiation of Late Latent Syphilis and False-Positive Serological Reactions: A Combination of ELISA and Discriminant Analysis.Bulletin of experimental biology and medicine · 2026Article
- Comparative performance of the traditional and reverse diagnostic algorithms for syphilis in pregnancy.Pregnancy (Hoboken, N.J.) · 2026Article
- Sexually transmitted infections in Brazilian adolescent offenders in correctional facilities.Revista panamericana de salud publica = Pan American journal of public health · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Infectious Diseases.Acta medica Philippina · 2026Article
- Estimating the sensitivity of non-treponemal and treponemal antibody tests in primary syphilis.medRxiv : the preprint server for health sciences · 2025Article
- Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic.Clinical chemistry · 2025Review
- A novel colorimetric immunosensor based on silk cocoon membrane-integrated ELISA for treponemal antibody detection.Microbiology spectrum · 2025Article
- Modeling the Impact of Time to Treatment on Syphilis Prevalence: A Theoretical Mathematical Model of People Living With HIV in Colombia.Sexually transmitted diseases · 2025Article
- Diagnostic performance ofSexually transmitted infections · 2025Article
- Alternative treponemal serology assays for diagnosis and confirmation of syphilis in a diagnostic laboratory: a retrospective evaluation of four agglutination assays and one ELISA.Journal of clinical microbiology · 2025Article
- B-Cell Epitope Mapping of theDiagnostics (Basel, Switzerland) · 2025Article
- Advancing syphilis diagnosis: multi-phase study evaluation of a TpN17-based double-antigen sandwich ELISA for detectingFrontiers in microbiology · 2025Article
- Article
- The population-level impact of introducing rapid diagnostic tests on syphilis transmission in Canadian arctic communities - a mathematical modeling study.Lancet regional health. Americas · 2024Article
- Ocular vs neurosyphilis. are they the same? A guide to investigation and management.Eye (London, England) · 2024Review
- Performance Assessment of Treponemal and Nontreponemal Tests for the Diagnosis of Acquired Syphilis.The American journal of tropical medicine and hygiene · 2024Article
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14 authors at 4 institutions in 1 country.
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Abstract
backgroundTreponemal immunoassays are increasingly used for syphilis screening with the reverse sequence algorithm. There are few data describing performance of treponemal immunoassays compared to traditional treponemal tests in patients with and without syphilis.
methodsWe calculated sensitivity and specificity of 7 treponemal assays: (1) ADVIA Centaur (chemiluminescence immunoassay [CIA]); (2) Bioplex 2200 (microbead immunoassay); (3) fluorescent treponemal antibody absorption test (FTA-ABS); (4) INNO-LIA (line immunoassay); (5) LIAISON CIA; (6) Treponema pallidum particle agglutination assay (TPPA); and (7) Trep-Sure (enzyme immunoassay [EIA]), using a reference standard combining clinical diagnosis and serology results. Sera were collected between May 2012-January 2013. Cases were characterized as: (1) current clinical diagnosis of syphilis: primary, secondary, early latent, late latent; (2) prior treated syphilis only; (3) no evidence of current syphilis, no prior history of syphilis, and at least 4 of 7 treponemal tests negative.
resultsAmong 959 participants, 262 had current syphilis, 294 had prior syphilis, and 403 did not have syphilis. FTA-ABS was less sensitive for primary syphilis (78.2%) than the immunoassays or TPPA (94.5%-96.4%) (all P ≤ .01). All immunoassays were 100% sensitive for secondary syphilis, 95.2%-100% sensitive for early latent disease, and 86.8%-98.5% sensitive in late latent disease. TPPA had 100% specificity.
conclusionsTreponemal immunoassays demonstrated excellent sensitivity for secondary, early latent, and seropositive primary syphilis. Sensitivity of FTA-ABS in primary syphilis was poor. Given its high specificity and superior sensitivity, TPPA is preferred to adjudicate discordant results with the reverse sequence algorithm over the FTA-ABS.
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