SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Osteomyelitis Complicating Sacral Pressure Ulcers: Whether or Not to Treat With Antibiotic Therapy.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Systematic review: investigating the added diagnostic value of gadolinium contrast agents for osteomyelitis in the appendicular skeleton.Skeletal radiology · 2022Pooled it
- Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma: A Systematic Review.The American journal of medicine · 2022Pooled it
- Effect of autologous concentrated growth factor on bedsore wounds in elderly patients with diabetes: a case-control study.Frontiers in endocrinology · 2025Trial
- Effect of a computerized decision support system on the treatment approach of stage III or IV pressure injury in patients with spinal cord injury: a feasibility study.BMC health services research · 2023Trial
- Prehabilitation for Pressure Ulcer Surgery: A Practical and Evidence-based Guide.Plastic and reconstructive surgery. Global open · 2026Article
- Short Against Long Antibiotic Therapy for Infected Orthopaedic Sites-2nd Interim Analysis of the SALATIO Trials.Journal of clinical medicine · 2026Article
- Transitioning to Shorter, Oral Antimicrobial Therapy for Pelvic Osteomyelitis in Patients Living With Spinal Cord Injury.Open forum infectious diseases · 2026Article
- Review
- Knockout of the Staphylococcus aureus virulence gene sdrC promotes Myh7 expression to inhibit the progression of osteomyelitis.Journal of molecular histology · 2025Article
- Flap reconstruction of pressure ulcers in patients with spinal cord injury: a retrospective cohort study.Spinal cord · 2025Article
- Management of pressure injuries with associated osteomyelitis in people with spinal cord injury: a national survey of referral centers in France.Spinal cord · 2025Review
- Clinical Presentation and Integrated Management of Pressure Injuries in the Emergency Hospital Setting: A Plastic Surgeon's Perspective.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Osteomyelitis in Late-Stage Pressure Sore Patients: A Retrospective Analysis.Life (Basel, Switzerland) · 2024Article
- New Agents Are Coming, and So Is the Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Healthcare utilization and outcomes of spinal cord injured veterans with stage 3-4 pressure injuries.The journal of spinal cord medicine · 2024Article
- Optimizing diagnosis and surgical decisions for chronic osteomyelitis through radiomics in the precision medicine era.Frontiers in bioengineering and biotechnology · 2024Article
- Anti-infective management of infected skin ulcers.Le infezioni in medicina · 2024Review
- Surgical Ulcer Debridement in a Patient With Spina Bifida Complicated by Osteomyelitis, Obesity, and Diabetes.Cureus · 2023Article
- A Survey of Orthopedic Surgical Management of Pressure Ulcer-Related Pelvic Osteomyelitis.Open forum infectious diseases · 2023Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The treatment of osteomyelitis in patients with stage IV sacral pressure ulcers is controversial. We conducted a systematic literature review and did not find evidence of benefit of antibacterial therapy in this setting without concomitant surgical debridement and wound coverage. Furthermore, many patients with chronically exposed bone do not have evidence of osteomyelitis when biopsied, and magnetic resonance imaging may not accurately distinguish osteomyelitis from bone remodeling. The goal of therapy should be local wound care and assessment for the potential of wound closure. If the wound can be closed and osteomyelitis is present on bone biopsy, appropriate antibiotic therapy is reasonable. We find no data to support antibiotic durations of >6 weeks in this setting, and some authors recommend 2 weeks of therapy if the osteomyelitis is limited to cortical bone. If the wound will not be closed, we find no clear evidence supporting a role for antibiotic therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.