ArticlePLoS computational biology2018
Differential roles of sleep spindles and sleep slow oscillations in memory consolidation.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Pooled it
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.Research square · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.bioRxiv : the preprint server for biology · 2026Article
- From Brain Networks to Sleep Perception: EEG-Derived Global Efficiency is Associated with Subjective Sleep Quality in University Students.Nature and science of sleep · 2026Article
- Unconscious switching of dorsal and medial pathways for plasticity and stability during NREM and REM sleep.bioRxiv : the preprint server for biology · 2025Article
- The effects of targeted reactivation on memories cued once or multiple times during a nap.Neuropsychologia · 2025Article
- AISleep: Automated and interpretable sleep staging from single-channel EEG data.Patterns (New York, N.Y.) · 2025Article
- Recent Evidence of Non-Rapid Eye Movement Sleep Oscillation Abnormalities in Psychiatric Disorders.Current psychiatry reports · 2025Review
- Hippocampal indexing alters the stability landscape of synaptic weight space allowing life-long learning.bioRxiv : the preprint server for biology · 2025Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.bioRxiv : the preprint server for biology · 2025Article
- Neurocognition After Perturbed Sleep (NAPS): A Protocol for an Experimental Study Examining the Impact of Sleep on Neurocognition, Functioning, and Clinical Indicators in People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- A unified framework to model synaptic dynamics during the sleep-wake cycle.PLoS biology · 2025Article
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep.Cerebral cortex (New York, N.Y. : 1991) · 2025Review
- Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function.Science advances · 2024Article
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Towards biologically plausible model-based reinforcement learning in recurrent spiking networks by dreaming new experiences.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sleep plays an important role in the consolidation of recent memories. However, the cellular and synaptic mechanisms of consolidation during sleep remain poorly understood. In this study, using a realistic computational model of the thalamocortical network, we tested the role of Non-Rapid Eye Movement (NREM) sleep in memory consolidation. We found that sleep spindles (the hallmark of N2 stage sleep) and slow oscillations (the hallmark of N3 stage sleep) both promote replay of the spike sequences learned in the awake state and replay was localized at the trained network locations. Memory performance improved after a period of NREM sleep but not after the same time period in awake. When multiple memories were trained, the local nature of the spike sequence replay during spindles allowed replay of the distinct memory traces independently, while slow oscillations promoted competition that could prevent replay of the weak memories in a presence of the stronger memory traces. This could lead to extinction of the weak memories unless when sleep spindles (N2 sleep) preceded slow oscillations (N3 sleep), as observed during the natural sleep cycle. Our study presents a mechanistic explanation for the role of sleep rhythms in memory consolidation and proposes a testable hypothesis how the natural structure of sleep stages provides an optimal environment to consolidate memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.