ArticleJournal of acquired immune deficiency syndromes (1999)2018
Smoking and Accelerated Lung Function Decline in HIV-Positive Individuals: A Secondary Analysis of the START Pulmonary Substudy.
Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Human Immunodeficiency Virus on Lung Function and Structure: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society · 2025Pooled it
- Identifying Metabolomic Biomarkers of Lung Function Decline in People with HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Pulmonary Immunocompromise in Human Immunodeficiency Virus Disease.Clinics in chest medicine · 2025Review
- Pulmonary symptoms associated with heavy alcohol consumption among people living with HIV: an analysis of the NHANES 1999-2010.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Combined effects of smoking and HIV infection on the occurrence of aging-related manifestations.Scientific reports · 2023Article
- Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.AIDS research and human retroviruses · 2023Article
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Article
- Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV.Scientific reports · 2023Article
- Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.Annals of the American Thoracic Society · 2022Article
- Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021Review
- Pulmonary Immune Dysregulation and Viral Persistence During HIV Infection.Frontiers in immunology · 2021Review
- Predictors of impaired pulmonary function in people living with HIV in an urban African setting.Southern African journal of HIV medicine · 2021Article
- Lung Function, Coronary Artery Disease, and Mortality in HIV.Annals of the American Thoracic Society · 2019Article
- Pathogenesis and management of emphysema in people with HIV.Expert review of respiratory medicineReview
- A Review of Chronic Comorbidities in Adults Living With HIV: State of the Science.The Journal of the Association of Nurses in AIDS Care : JANACReview
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a leading cause of death and disability globally. Both cigarette smoking and HIV have been identified as independent risk factors for COPD. We used data from the strategic timing of antiretroviral treatment (START) Pulmonary Substudy to quantify the impact of smoking on rate of lung function decline in HIV.
methodsWe included START Pulmonary Substudy participants who contributed at least 2 good quality spirometry measures during the study. Slope of forced expiratory volume in 1 second (FEV1) was estimated using a repeated-measures model adjusted for the treatment group (immediate vs deferred treatment arm of START), age, sex, race, baseline COPD, and region.
resultsOf 1026 START Pulmonary Substudy participants, 915 (89%) were included in this analysis. Median follow-up time was 3.9 years. Smokers and nonsmokers were similar in baseline age (median 36 years), but smokers were more likely to be white, male, and from Europe/Israel/Australia. Smokers had faster average FEV1 decline compared with nonsmokers [-38.3 mL/yr vs -25.1 mL/yr; difference of -13.2 mL/yr (95% confidence interval: -23.6 to -2.7); P = 0.013], were more likely to meet criteria for rapid FEV1 decline [7.2%-11.7% more likely (P = 0.09-P = 0.002), depending on the definition of rapid decline], and had borderline, but not statistically significant, higher incident COPD during follow-up (9.7% vs 5.8%, P = 0.06).
conclusionsCompared to nonsmokers, HIV-positive smokers experience faster decline in lung function. These results underscore the need for a better understanding of how to best support smoking cessation among HIV-positive populations.
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