ArticleScientific reports2018
Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Movement Ecology and Disease Exposure in Free-Roaming Donkeys in California, USA.Animals : an open access journal from MDPI · 2026Article
- Detection of equine herpesvirus antibodies in large-scale donkey farms in Liaocheng area.Veterinary medicine and science · 2024Article
- Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway.Frontiers in cellular and infection microbiology · 2024Article
- Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand.Animals : an open access journal from MDPI · 2023Article
- Kinetics of the Equid Herpesvirus 2 and 5 Infections among Mares and Foals from Three Polish National Studs.Viruses · 2022Article
- A meta-analysis of impacts of immune response and infection on oxidative status in vertebrates.Conservation physiology · 2022Article
- Patterns of Genital TractBiomolecules · 2021Article
- Noninvasive Detection of Equid Herpesviruses in Fecal Samples.Applied and environmental microbiology · 2019Article
- Comparative Health Assessments of Alaskan Ice Seals.Frontiers in veterinary science · 2019Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 10 countries.
Funding
Abstract
Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse (Equus ferus caballus) and of both captive and free-ranging Mongolian khulan (Equus hemionus hemionus) and plains zebra (Equus quagga). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.