Evidence map›Paper›PMID 29985427›Full record

ArticleScientific reports2018

Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.

Kenneth P Hough, Landon S Wilson, Jennifer L Trevor, John G Strenkowski, Njeri Maina, Young-Il Kim, Marion L Spell, Yong Wang, Diptiman Chanda, Jose Rodriguez Dager and 11 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 115 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. The dual promise of extracellular vesicles in lung diseases: towards reliable biomarkers and drug delivery vectors.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  6. Article
  7. Review
  8. Mouse TThe Journal of allergy and clinical immunology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Lipids in Equine Airway Inflammation: An Overview of Current Knowledge.Animals : an open access journal from MDPI · 2024
    Review
  17. Review
  18. Review
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Kenneth P HoughDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Landon S WilsonDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer L TrevorDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
John G StrenkowskiDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Njeri MainaDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Young-Il KimDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Marion L SpellCenter for AIDS Research, University of Alabama at Birmingham, Birmingham, AL, USA.
Yong WangDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Diptiman ChandaDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jose Rodriguez DagerDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Nirmal S SharmaDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Miranda CurtissDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Veena B AntonyDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Mark T DransfieldDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David D ChaplinDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1354-3069
Chad SteeleDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephen BarnesDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-6837-1674
Steven R DuncanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeevan K PrasainDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor J ThannickalDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessy S DeshaneDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. jessydeshane@uabmc.edu.
University of Alabama at Birmingham · USTarget (United States) · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseP01HL114470 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2013 to 2022
$17.8M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Metabolic Landscape of the Aging LungR01HL152246 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, JARROD W., THANNICKAL, VICTOR J. · 2020 to 2023
$3.2M
Environmental Cadmium and COPDR01ES029981 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANTONY, VEENA B. · 2018 to 2022
$2.5M
Myeloid-Derived Regulatory Cells in AsthmaR01HL128502 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DESHANE, JESSY SATYADAS · 2016 to 2020
$1.8M
Metabolic drivers and sensors of cell proliferation in pulmonary hypertensionR00HL131866 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, JARROD W. · 2018 to 2020
$731k
BLRD VA I01 BX003056Flight Attendant Medical Research Institute (FAMRI) FAMRI YCSA 2010NHLBI NIH HHS P01 HL114470NHLBI NIH HHS R00 HL131866NHLBI NIH HHS R01 HL128502NHLBI NIH HHS R01 HL152246NIAMS NIH HHS P30 AR048311NIEHS NIH HHS R01 ES029981
6 · The paper itself

Abstract

Asthma is a chronic inflammatory disease process involving the conductive airways of the human lung. The dysregulated inflammatory response in this disease process may involve multiple cell-cell interactions mediated by signaling molecules, including lipid mediators. Extracellular vesicles (EVs) are lipid membrane particles that are now recognized as critical mediators of cell-cell communication. Here, we compared the lipid composition and presence of specific lipid mediators in airway EVs purified from the bronchoalveolar lavage (BAL) fluid of healthy controls and asthmatic subjects with and without second-hand smoke (SHS) exposure. Airway exosome concentrations were increased in asthmatics, and correlated with blood eosinophilia and serum IgE levels. Frequencies of HLA-DR

Indexed as

AdultAgedAsthmaBronchoalveolar Lavage FluidCase-Control StudiesCeramidesDiscriminant AnalysisDown-RegulationExosomesExtracellular VesiclesFemaleHLA-DR AntigensHumansImmunoglobulin EIntercellular Adhesion Molecule-1MaleCeramidesHLA-DR AntigensImmunoglobulin EIntercellular Adhesion Molecule-1PhosphatidylglycerolsSphingomyelinsTobacco Smoke Pollution

Identifiers

PMID29985427
PMCPMC6037776
OpenAlexW2811343415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.