Evidence map›Paper›PMID 29985423›Full record

ArticleScientific reports2018

Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats.

Aline Maria Arlindo de Souza, Crystal A West, Aline Rezende Ribeiro de Abreu, Amrita V Pai, Laura Batista Tavares Mesquita, Hong Ji, Deoclécio Chianca, Rodrigo Cunha Alvim de Menezes, Kathryn Sandberg

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Aline Maria Arlindo de SouzaDepartment of Medicine, Georgetown University, Washington, DC, 20057, USA. aa1617@georgetown.edu.ORCID 0000-0002-7031-2523
Crystal A WestDepartment of Medicine, Georgetown University, Washington, DC, 20057, USA.
Aline Rezende Ribeiro de AbreuDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Amrita V PaiDepartment of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC, 20057, USA.
Laura Batista Tavares MesquitaDepartamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35460-000, Brazil.
Hong JiDepartment of Medicine, Georgetown University, Washington, DC, 20057, USA.
Deoclécio ChiancaDepartamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35460-000, Brazil.
Rodrigo Cunha Alvim de MenezesDepartamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35460-000, Brazil.
Kathryn SandbergDepartment of Medicine, Georgetown University, Washington, DC, 20057, USA.
Georgetown University · USUniversidade Federal de Ouro Preto · BRIndiana University School of Medicine

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Translational Biomedical Science Training GrantTL1TR001431 · NCATS · GEORGETOWN UNIVERSITY · PI LEE, DEXTER L, SANDBERG, KATHRYN L · 2015 to 2024
$4.8M
Immune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4M
NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR001409NHLBI NIH HHS R01 HL119380
6 · The paper itself

Abstract

Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40% of CT) diet for 14 days. In response to severe FR, BP allostasis was achieved by up-regulating circulating Ang-[1-8] by 1.3-fold through increased angiotensin converting enzyme (ACE) activity and by increasing the expression of AT

Indexed as

AllostasisBlood PressureDietAldosteroneAngiotensinogenAngiotensinsAnimalsFemaleLosartanMesenteric VeinsPeptidyl-Dipeptidase APhenylephrineRatsRats, Inbred F344Receptor, Angiotensin, Type 1ReninAldosteroneAngiotensinogenAngiotensinsLosartanPeptidyl-Dipeptidase APhenylephrineReceptor, Angiotensin, Type 1Renin

Identifiers

PMID29985423
PMCPMC6037681
OpenAlexW2810655008

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.