ArticleJournal of visualized experiments : JoVE2018
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses.
Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice.BMC complementary medicine and therapies · 2024Article
- Differential skin immune responses in mice intradermally infected withMicrobiology spectrum · 2023Article
- Effects of 3% Boric Acid Solution on CutaneousFrontiers in microbiology · 2021Article
- Visualizing Hypoxia in a Murine Model ofBio-protocol · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The skin is an extremely extended organ of the body and, due to this large surface, it is continuously exposed to microorganisms. Skin damage can easily lead to infections in the dermis which can, in turn, result in the dissemination of pathogens into the bloodstream. Understanding how the immune system fights infections at the very early stage and how the host can eliminate the pathogens is an important step to set the base for future therapeutic interventions. Here we describe a model of Candida albicans infection that can visualize the processes that occur early during an infection, including when the pathogen has passed the epithelial barrier, as well as the immune response elicited by the C. albicans invasion. We used this infection model to perform histological analyses that show the immune cells that infiltrate the skin as well as the presence and localization of the pathogen. Samples collected after the infection can be processed for RNA extraction.
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Registered trials
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