Evidence map›Paper›PMID 29985130›Full record

ArticleeLife2018

JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the

Salvador C Herrera, Erika A Bach

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Stem cell competition.Current topics in developmental biology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. c-Jun N-terminal kinase signaling in aging.Frontiers in aging neuroscience · 2024
    Review
  18. rDNA magnification is a unique feature of germline stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Salvador C HerreraNew York University School of Medicine, New York, United States.
Erika A BachNew York University School of Medicine, New York, United States.ORCID http://orcid.org/0000-0002-5997-4489
New York University · US

Funding

Eludicating the Molecular Mechanisms That Regulate Stem Cell Numbers in VivoR01GM085075 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2009 to 2023
$4.3M
NIGMS NIH HHS R01 GM085075
6 · The paper itself

Abstract

Exhaustion of stem cells is a hallmark of aging. In the

Indexed as

Cell DedifferentiationMAP Kinase Signaling SystemStress, PhysiologicalAgingAnimalsCell LineageDrosophila melanogasterEnzyme ActivationMaleModels, BiologicalSpermatogenesisSpermatogoniaStem CellsTestisagingdedifferentiationdevelopmental biologydifferentiationD. melanogastergermline stem cellJun N-terminal kinaseregenerative medicinestem cellstestis

Identifiers

PMID29985130
PMCPMC6070334
OpenAlexW2852804580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.